DNA vaccines for emerging infectious diseases: what if?

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Whalen, R. G.
• Description:
  A novel and powerful method for vaccine research, colloquially known as DNA vaccines, involves the deliberate introduction into tissues of a DNA plasmid carrying an antigen-coding gene that transfects cells in vivo and results in an immune response. DNA vaccines have several distinct advantages, which include ease of manipulation, use of a generic technology, simplicity of manufacture, and chemical and biological stability. In addition, DNA vaccines are a great leveler among re-searchers around the world because they provide unprecedented ease of experi-mentation. To facilitate diffusion of information, an Internet site has been established called THE DNA VACCINE WEB (URL:http://www.genweb.com/dnavax/dnavax.html). In this review, a brief survey is undertaken of the experimental models and preclinical work on DNA vaccines to contribute to a greater awareness of the possibilities for emerging infectious diseases.
• Subjects:
  Animals Communicable Disease Control Communicable Diseases Disease Models, Animal Humans Research Vaccines, DNA
• Source:
  Emerg Infect Dis. 2(3):168-175.
• Document Type:
  Journal Article
• Volume:
  2
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:0459f8cc0ad7d71cec29c98c79351e6d7245b3905235dd5f396ebaf44c7f1cb3
• Download URL:
  https://stacks.cdc.gov/view/cdc/15320/cdc_15320_DS1.pdf
• File Type:
  [PDF - 41.29 KB ]