Isolation of Diverse Simian Arteriviruses Causing Hemorrhagic Disease

Shaw, Teressa M.; Dettle, Samuel T.; Mejia, Andres; Hayes, Jennifer M.; Simmons, Heather A.; Basu, Puja; Kuhn, Jens H.; Ramuta, Mitchell D.; Warren, Cody J.; Jahrling, Peter B.; O’Connor, David H.; Huang, Liupei; Zaeem, Misbah; Seo, Jiwon; Slukvin, Igor I.; Brown, Matthew E.; Bailey, Adam L.

doi:10.3201/eid3004.231457

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Isolation of Diverse Simian Arteriviruses Causing Hemorrhagic Disease

4 2024
By Shaw, Teressa M. ; Dettle, Samuel T. ; Mejia, Andres ; ...
http://dx.doi.org/10.3201/eid3004.231457
Source: Emerg Infect Dis. 2024; 30(4):721-731

[PDF-4.71 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Shaw, Teressa M. ; Dettle, Samuel T. ; Mejia, Andres ; Hayes, Jennifer M. ; Simmons, Heather A. ; ... More +

Shaw, Teressa M. ; Dettle, Samuel T. ; Mejia, Andres ; Hayes, Jennifer M. ; Simmons, Heather A. ; Basu, Puja ; Kuhn, Jens H. ; Ramuta, Mitchell D. ; Warren, Cody J. ; Jahrling, Peter B. ; O’Connor, David H. ; Huang, Liupei ; Zaeem, Misbah ; Seo, Jiwon ; Slukvin, Igor I. ; Brown, Matthew E. ; Bailey, Adam L. Less -
Description:

Genetically diverse simian arteriviruses (simarteriviruses) naturally infect geographically and phylogenetically diverse monkeys, and cross-species transmission and emergence are of considerable concern. Characterization of most simarteriviruses beyond sequence analysis has not been possible because the viruses fail to propagate in the laboratory. We attempted to isolate 4 simarteriviruses, Kibale red colobus virus 1, Pebjah virus, simian hemorrhagic fever virus, and Southwest baboon virus 1, by inoculating an immortalized grivet cell line (known to replicate simian hemorrhagic fever virus), primary macaque cells, macrophages derived from macaque induced pluripotent stem cells, and mice engrafted with macaque CD34+-enriched hematopoietic stem cells. The combined effort resulted in successful virus isolation; however, no single approach was successful for all 4 simarteriviruses. We describe several approaches that might be used to isolate additional simarteriviruses for phenotypic characterization. Our results will expedite laboratory studies of simarteriviruses to elucidate virus-host interactions, assess zoonotic risk, and develop medical countermeasures.
Subjects:

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Animals Arterivirus Cell Line Macaca Macrophages Mice
Keywords:

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Arterivirid Arteriviridae Arterivirus Bacteria Burkholderia Pseudomallei Engraft History Induced Pluripotent Stem Cell IPSC Kibale Red Colobus Virus KRCV-1 Melioidosis NHP Nonhuman Primate PBJV Pebjah Virus SHFV Simarterivirin Simarterivirinae Simarterivirus Simian Hemorrhagic Fever Virus Southwest Baboon Virus SWBV United States Viruses Zoonoses
Source:

Emerg Infect Dis. 2024; 30(4):721-731
Pubmed ID:

38526136
Pubmed Central ID:

PMC10977827
Document Type:

Journal Article
Funding:

P30 CA014520/CA/NCI NIH HHSUnited States/ ; R00 AI151256/AI/NIAID NIH HHSUnited States/ ; HHSN272201800013C/AI/NIAID NIH HHSUnited States/ ; P51 OD011106/OD/NIH HHSUnited States/ ; 75N93021C00004/AI/NIAID NIH HHSUnited States/ ; ... More +

P30 CA014520/CA/NCI NIH HHSUnited States/ ; R00 AI151256/AI/NIAID NIH HHSUnited States/ ; HHSN272201800013C/AI/NIAID NIH HHSUnited States/ ; P51 OD011106/OD/NIH HHSUnited States/ ; 75N93021C00004/AI/NIAID NIH HHSUnited States/ ; C06 RR020141/RR/NCRR NIH HHSUnited States/ ; C06 RR015459/RR/NCRR NIH HHSUnited States/ ; U01 HL134764/HL/NHLBI NIH HHSUnited States/ ; R01 HD103443/HD/NICHD NIH HHSUnited States/ Less -
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:e0d0fea8498333cea49f8e17c8a14e5e6d4f206b5e89285077b5cfe41aa16eef
Download URL:

https://stacks.cdc.gov/view/cdc/152966/cdc_152966_DS1.pdf
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