Geographic Disparities in Domestic Pig Population Exposure to Ebola Viruses, Guinea, 2017–2019

Grayo, Solène; Camara, Alimou; Doukouré, Bakary; Ellis, Isabelle; Troupin, Cécile; Fischer, Kerstin; Vanhomwegen, Jessica; White, Michael; Groschup, Martin H.; Diederich, Sandra; Tordo, Noël

doi:10.3201/eid3004.231034

i

Geographic Disparities in Domestic Pig Population Exposure to Ebola Viruses, Guinea, 2017–2019

Supporting Files Public Domain

4 2024
By Grayo, Solène ; Camara, Alimou ; Doukouré, Bakary ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Grayo, Solène ; Camara, Alimou ; Doukouré, Bakary ; Ellis, Isabelle ; Troupin, Cécile ; Fischer, Kerstin ; Vanhomwegen, Jessica ; White, Michael ; Groschup, Martin H. ; Diederich, Sandra ; Tordo, Noël
Description:

Although pigs are naturally susceptible to Reston virus and experimentally to Ebola virus (EBOV), their role in Orthoebolavirus ecology remains unknown. We tested 888 serum samples collected from pigs in Guinea during 2017-2019 (between the 2013-16 epidemic and its resurgence in 2021) by indirect ELISA against the EBOV nucleoprotein. We identified 2 hotspots of possible pig exposure by IgG titer levels: the northern coast had 48.7% of positive serum samples (37/76), and Forest Guinea, bordering Sierra Leone and Liberia, where the virus emerged and reemerged, had 50% of positive serum samples (98/196). The multitarget Luminex approach confirms ELISA results against Ebola nucleoprotein and highlights cross-reactivities to glycoprotein of EBOV, Reston virus, and Bundibugyo virus. Those results are consistent with previous observations of the circulation of Orthoebolavirus species in pig farming regions in Sierra Leone and Ghana, suggesting potential risk for Ebola virus disease in humans, especially in Forest Guinea.
Subjects:

Animals Ebolavirus Hemorrhagic Fever, Ebola Humans Nucleoproteins Sus Scrofa Swine
Keywords:

Bacteria Burkholderia Pseudomallei Ebola Virus Guinea History Melioidosis Pigs Serology Swine Viruses West Africa
Source:

Emerg Infect Dis. 2024; 30(4):681-690
Pubmed ID:

38526081
Pubmed Central ID:

PMC10977825
Document Type:

Journal Article
Place as Subject:

Guinea ; Sierra Leone
Volume:

30
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:73fc809d5ebb91ca9be46094579f25590cb225f548bd5476b1468061f8de96cd
Download URL:

https://stacks.cdc.gov/view/cdc/152949/cdc_152949_DS1.pdf
File Type:

[PDF - 2.71 MB ]

File Language:

English

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