Correlation of SARS-CoV-2 in Wastewater and Individual Testing Results in a Jail, Atlanta, Georgia, USA

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Saber, Lindsay B. ; Kennedy, Shanika S. ; Yang, Yixin ; Moore, Kyler N. ; Wang, Yuke ; Hilton, Stephen P. ; Chang, Tylis Y. ; Liu, Pengbo ; Phillips, Victoria L. ; Akiyama, Matthew J. ; Moe, Christine L. ; Spaulding, Anne C.
• Description:
  Institution-level wastewater-based surveillance was implemented during the COVID-19 pandemic, including in carceral facilities. We examined the relationship between COVID-19 diagnostic test results of residents in a jail in Atlanta, Georgia, USA (average population ≈2,700), and quantitative reverse transcription PCR signal for SARS-CoV-2 in weekly wastewater samples collected during October 2021‒May 2022. The jail offered residents rapid antigen testing at entry and periodic mass screenings by reverse transcription PCR of self-collected nasal swab specimens. We aggregated individual test data, calculated the Spearman correlation coefficient, and performed logistic regression to examine the relationship between strength of SARS-CoV-2 PCR signal (cycle threshold value) in wastewater and percentage of jail population that tested positive for COVID-19. Of 13,745 nasal specimens collected, 3.9% were COVID-positive (range 0%-29.5% per week). We observed a strong inverse correlation between diagnostic test positivity and cycle threshold value (r = -0.67; p<0.01). Wastewater-based surveillance represents an effective strategy for jailwide surveillance of COVID-19.
• Subjects:
  Animals COVID-19 Gastropoda Humans Jails Pandemics RNA, Viral SARS-CoV-2 Wastewater
• Keywords:
  Atlanta Bacteria Burkholderia Pseudomallei Coronaviruses Correctional Epidemiology Georgia History Jail Melioidosis Respiratory Infections United States Virus Detection Method Viruses Wastewater-based Surveillance Zoonoses

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• Source:
  Emerg Infect Dis. 2024; 30(Suppl 1):S21-S27
• Pubmed ID:
  38561638
• Pubmed Central ID:
  PMC10986836
• Document Type:
  Journal Article
• Funding:
  75N92021C00012/HL/NHLBI NIH HHSUnited States/ ; INV-035562/GATES/Bill & Melinda Gates FoundationUnited States/
• Place as Subject:
  Atlanta, GA
• Volume:
  30
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:317109f0c3e9019f1495730baa8b087bb30b9710714bf19d1f93c9c83628704d
• Download URL:
  https://stacks.cdc.gov/view/cdc/152936/cdc_152936_DS1.pdf
• File Type:
  [PDF - 1.54 MB ]