Hantavirus Seroconversion of Wild-Caught Peromyscus During Quarantine

Details

• Journal Article:
  Emerging Infectious Diseases
• Personal Author:
  Camaioni, M. ; Botten, J. ; Hjelle, B. ; Loew, S. S.
• Description:
  In 1993 an outbreak of unexplained respiratory deaths in the Four Corners region of the United States led to the discovery of Sin Nombre (SN) hantavirus and the associated human disease, hantavirus cardiopulmonary syndrome (HCPS). Numerous studies have shown that a series of hantaviruses similar to SN virus are maintained in natural reservoirs composed of Sigmodontine rodents, including deer mice (Peromyscus maniculatus), white-footed mice (P. leucopus), cotton rats (Sigmodon hispidus) and western harvest mice (Reithrodontomys megalotis). Deer mice, however, are the principal reservoir of SN virus, the primary etiologic agent of HCPS in North America. Some hantaviruses, thus far not including SN virus, have been transmitted in indoor animal-care facilities through the airborne route. The high case-fatality ratio of HCPS (40%), coupled with its airborne transmission by captive rodents, has led to classification of the agents of HCPS as biosafety level 3 (BSL-3) in tissue culture and BSL-4 in reservoir host rodents. Although deer mice mount an antibody response and develop chronic infection, the virus does not harm them. Deer mice are believed to shed SN virus in urine, feces, and saliva. Infection in humans occurs primarily by inhalation of aerosols from dried excreta containing infectious virus, particularly in closed spaces with poor ventilation.
• Subjects:
  Animals Hantavirus Infections Orthohantavirus Peromyscus Quarantine Seroepidemiologic Studies Zoonoses
• Series:
  Emerging Infectious Diseases
• DOI:
  https://doi.org/10.3201/eid0703.010329
• ISSN:
  1080-6059 (digital) ; 1080-6040 (print)
• Publisher:
  Centers for Disease Control and Prevention (CDC) (U.S.)
• Pubmed ID:
  11384539
• Pubmed Central ID:
  PMC2631788
• Document Type:
  Text
• Genre:
  Letter
• Rights:
  Public Domain
• Topic:
  Diseases & Conditions
• Volume:
  7
• Issue:
  3
• Citation:
  Emerg Infect Dis. 7(3):482-483.
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:80fbc01b0f18ff0ea9fa5cc865cb6569b4df7fbba0d186d1ef72be2a7b7259b6c6f86a90c6fe0edeb0d4b1388471d8d59fb8063e0fac804b5197b6a860ee88a2
• Download URL:
  https://stacks.cdc.gov/view/cdc/15134/cdc_15134_DS1.pdf
• File Type:
  [PDF - 42.07 KB ]