Transferable plasmid-mediated resistance to streptomycin in a clinical isolate of Yersinia pestis.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Guiyoule, A. ; Gerbaud, G. ; Buchrieser, C. ; Galimand, M. ; Rahalison, L. ; Chanteau, S. ; Courvalin, P. ; Carniel, E.
• Description:
  Plasmid-mediated high-level resistance to multiple antibiotics was reported in a clinical isolate of Yersinia pestis in Madagascar in 1997. We describe a second Y. pestis strain with high-level resistance to streptomycin, isolated from a human case of bubonic plague in Madagascar. The resistance determinants were carried by a self-transferable plasmid that could conjugate at high frequencies to other Y. pestis isolates. The plasmid and the host bacterium were different from those previously associated with multiple-drug resistance, indicating that acquisition of resistance plasmids is occurring in this bacterial species. Emergence of resistance to streptomycin in Y. pestis represents a critical public health problem since this antibiotic is used as the first-line treatment against plague in many countries.
• Subjects:
  Conjugation, Genetic Humans R Factors Streptomycin Yersinia Pestis
• Source:
  Emerg Infect Dis. 7(1):43-48.
• Document Type:
  Journal Article
• Volume:
  7
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9f386a8efe684b851b37162540995df5539524bed31467b92a884473720f1722
• Download URL:
  https://stacks.cdc.gov/view/cdc/15061/cdc_15061_DS1.pdf
• File Type:
  [PDF - 101.47 KB ]