Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Guiyoule, A. ; Gerbaud, G. ; Buchrieser, C. ; Galimand, M. ; Rahalison, L. ; ... More +
Guiyoule, A. ; Gerbaud, G. ; Buchrieser, C. ; Galimand, M. ; Rahalison, L. ; Chanteau, S. ; Courvalin, P. ; Carniel, E. ; Less -
Description:
Plasmid-mediated high-level resistance to multiple antibiotics was reported in a clinical isolate of Yersinia pestis in Madagascar in 1997. We describe a second Y. pestis strain with high-level resistance to streptomycin, isolated from a human case of bubonic plague in Madagascar. The resistance determinants were carried by a self-transferable plasmid that could conjugate at high frequencies to other Y. pestis isolates. The plasmid and the host bacterium were different from those previously associated with multiple-drug resistance, indicating that acquisition of resistance plasmids is occurring in this bacterial species. Emergence of resistance to streptomycin in Y. pestis represents a critical public health problem since this antibiotic is used as the first-line treatment against plague in many countries.
Subject:
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Conjugation, Genetic
Humans
Research Article
R Factors
Streptomycin
Yersinia Pestis

Source:
Emerg Infect Dis. 7(1):43-48.
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:9f386a8efe684b851b37162540995df5539524bed31467b92a884473720f1722
File Type:

Supporting Files

• 	11266293.nxml	txt
  	license.txt	txt

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