Diphtheria antitoxin levels in the Netherlands: a population-based study.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  de Melker, H. E. ; Berbers, G. A. ; Nagelkerke, N. J. ; Conyn-van Spaendonck, M. A.
• Description:
  In a population-based study in the Netherlands, diphtheria antitoxin antibodies were measured with a toxin-binding inhibition assay in 9, 134 sera from the general population and religious communities refusing vaccination. The Dutch immunization program appears to induce long-term protection against diphtheria. However, a substantial number of adults born before the program was introduced had no protective diphtheria antibody levels. Although herd immunity seems adequate, long-term population protection cannot be assured. As more than 60% of orthodox reformed persons have antibody levels lower than 0.01 IU/ml, introduction of diphtheria into religious communities refusing vaccination may constitute a danger of spread of the bacterium.
• Subjects:
  Adolescent Adult Aged Age Distribution Antibodies, Bacterial Child Child, Preschool Diphtheria Diphtheria Antitoxin Diphtheria Toxoid Female Humans Infant Male Middle Aged Population Surveillance Sex Distribution

  More +
• Source:
  Emerg Infect Dis. 5(5):694-700.
• Document Type:
  Journal Article
• Place as Subject:
  Netherlands
• Volume:
  5
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:dbfdab4c90f44f2454d090a5c4b27b1c87a76f0bc7a0cbe7b01146645b0f7d46
• Download URL:
  https://stacks.cdc.gov/view/cdc/14904/cdc_14904_DS1.pdf
• File Type:
  [PDF - 124.03 KB ]