Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Wizemann, T. M. ; Adamou, J. E. ; Langermann, S.
Wizemann, T. M. ; Adamou, J. E. ; Langermann, S. Less -
Description:
Blocking the primary stages of infection, namely bacterial attachment to host cell receptors and colonization of the mucosal surface, may be the most effective strategy to prevent bacterial infections. Bacterial attachment usually involves an interaction between a bacterial surface protein called an adhesin and the host cell receptor. Recent preclinical vaccine studies with the FimH adhesin (derived from uropathogenic Escherichia coli) have confirmed that antibodies elicited against an adhesin can impede colonization, block infection, and prevent disease. The studies indicate that prophylactic vaccination with adhesins can block bacterial infections. With recent advances in the identification, characterization, and isolation of other adhesins, similar approaches are being explored to prevent infections, from otitis media and dental caries to pneumonia and sepsis.
Subject:
[+]
Adhesins, Bacterial
Adhesins, Escherichia Coli
Antibodies, Bacterial
Bacterial Adhesion
Bacterial Infections
Bacterial Vaccines
Fimbriae Proteins
Gram-Negative Bacteria
Gram-Positive Bacteria
Humans

Source:
Emerg Infect Dis. 5(3):395-403.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:56415ed2c508e191721dc545aa45d5f95bc22685f0447ceab25750d1a2ffadbb
File Type:

Supporting Files

• 	10341176.nxml	txt
  	license.txt	txt

More +