Human herpesvirus 6: An emerging pathogen.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Campadelli-Fiume, G. ; Mirandola, P. ; Menotti, L.
• Description:
  Infections with human herpesvirus 6 (HHV-6), a beta-herpesvirus of which two variant groups (A and B) are recognized, is very common, approaching 100% in seroprevalence. Primary infection with HHV-6B causes roseola infantum or exanthem subitum, a common childhood disease that resolves spontaneously. After primary infection, the virus replicates in the salivary glands and is shed in saliva, the recognized route of transmission for variant B strains; it remains latent in lymphocytes and monocytes and persists at low levels in cells and tissues. Not usually associated with disease in the immunocompetent, HHV-6 infection is a major cause of opportunistic viral infections in the immunosuppressed, typically AIDS patients and transplant recipients, in whom HHV-6 infection/reactivation may culminate in rejection of transplanted organs and death. Other opportunistic viruses, human cytomegalovirus and HHV-7, also infect or reactivate in persons at risk. Another disease whose pathogenesis may be correlated with HHV-6 is multiple sclerosis. Data in favor of and against the correlation are discussed.
• Subjects:
  Adult Central Nervous System Diseases Child Exanthema Subitum Genome, Viral Herpesviridae Infections Herpesvirus 6, Human Herpesvirus 7, Human Humans Multiple Sclerosis Opportunistic Infections Sarcoma, Kaposi

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• Source:
  Emerg Infect Dis. 5(3):353-366.
• Document Type:
  Journal Article
• Volume:
  5
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:7fe9c75571bdbffb32855cd83fb7ad705390780a7e8236876524121197e149fb
• Download URL:
  https://stacks.cdc.gov/view/cdc/14840/cdc_14840_DS1.pdf
• File Type:
  [PDF - 527.20 KB ]