Fungal diversity in homes and asthma morbidity among school-age children in New York City

Cochran, Samuel J.; Acosta, Luis; Divjan, Adnan; Lemons, Angela R.; Rundle, Andrew G.; Miller, Rachel L.; Sobek, Edward; Green, Brett J.; Perzanowski, Matthew S.; Dannemiller, Karen C.

doi:10.1016/j.envres.2023.117296

Advanced Search

Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

Advanced Search
Custom Query

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Clear All

Query Builder

Query box

Clear All

For additional assistance using the Custom Query please check out our Help Page

Fungal diversity in homes and asthma morbidity among school-age children in New York City

12 15 2023
By Cochran, Samuel J. ; Acosta, Luis ; Divjan, Adnan ; ...
Source: Environ Res. 239(Pt 1):117296

Public Access Version Available on: December 15, 2024, 12:00 AM

Please check back on the date listed above.

English

Details You May Also Like

Details:

Alternative Title:

Environ Res
Personal Author:

Cochran, Samuel J. ; Acosta, Luis ; Divjan, Adnan ; Lemons, Angela R. ; Rundle, Andrew G. ; ... More +

Cochran, Samuel J. ; Acosta, Luis ; Divjan, Adnan ; Lemons, Angela R. ; Rundle, Andrew G. ; Miller, Rachel L. ; Sobek, Edward ; Green, Brett J. ; Perzanowski, Matthew S. ; Dannemiller, Karen C. Less -
Description:

BACKGROUND

Asthma development has been inversely associated with exposure to fungal diversity. However, the influence of fungi on measures of asthma morbidity is not well understood.

OBJECTIVES

This study aimed to test the hypothesis that fungal diversity is inversely associated with neighborhood asthma prevalence and identify specific fungal species associated with asthma morbidity.

METHODS

Children aged 7–8 years (n=347) living in higher (11–18%) and lower (3–9%) asthma prevalence neighborhoods were recruited within an asthma case-control study. Fungal communities were analyzed from floor dust using high-throughput DNA sequencing. A subset of asthmatic children (n=140) was followed to age 10–11 to determine asthma persistence.

RESULTS

Neighborhood asthma prevalence was inversely associated with fungal species richness (P=0.010) and Shannon diversity (P=0.059). Associations between neighborhood asthma prevalence and diversity indices were driven by differences in building type and presence of bedroom carpet. Among children with asthma at age 7–8 years, Shannon fungal diversity was inversely associated with frequent asthma symptoms at that age (OR 0.57, P=0.025) and with asthma persistence to age 10–11 (OR 0.48, P=0.043). Analyses of individual fungal species did not show significant associations with asthma outcomes when adjusted for false discovery rates.

DISCUSSION

Lower fungal diversity was associated with asthma symptoms in this urban setting. Individual fungal species associated with asthma morbidity were not detected. Further research is warranted into building type, carpeting, and other environmental characteristics which influence fungal exposures in homes.
Keywords:

[+]

Asthma Built-environment Case-Control Studies Child DNA Dust Fungi House-dust Humans Morbidity Mycobiome New York City
Source:

Environ Res. 239(Pt 1):117296
Pubmed ID:

37806477
Pubmed Central ID:

PMC10842248
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; P30 CA016058/CA/NCI NIH HHSUnited States/ ; P30 ES009089/ES/NIEHS NIH HHSUnited States/ ; R01 ES014400/ES/NIEHS NIH HHSUnited States/

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; P30 CA016058/CA/NCI NIH HHSUnited States/ ; P30 ES009089/ES/NIEHS NIH HHSUnited States/ ; R01 ES014400/ES/NIEHS NIH HHSUnited States/ Less -
Volume:

239
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha-512:a5104ebbb73ed6b91b654a8e23635317941bab2ebdf46803f879451a550c357cd0b89972df613c1a37114b8f007fb188b33fa9a03b502ed93c8338f0e9394f93
File Type:

Supporting Files:

No Additional Files

More +