Parechovirus A Circulation and Testing Capacities in Europe, 2015–2021

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bubba, Laura ; Broberg, Eeva K. ; Fischer, Thea K. ; Simmonds, Peter ; Harvala, Heli
• Corporate Authors:
  European Non-polio Enterovirus Network working group
• Description:
  Parechovirus infections usually affect neonates and young children; manifestations vary from asymptomatic to life-threatening. We describe laboratory capacity in Europe for assessing parechovirus circulation, seasonality, and epidemiology. We used retrospective anonymized data collected from parechovirus infection case-patients identified in Europe during January 2015-December 2021. Of 21 laboratories from 18 countries that participated in the study, 16 (76%) laboratories with parechovirus detection capacity reported 1,845 positive samples; 12/16 (75%) with typing capability successfully identified 517 samples. Parechovirus A3 was the most common type (n = 278), followed by A1 (153), A6 (50), A4 (13), A5 (22), and A14 (1). Clinical data from 1,269 participants highlighted correlation of types A3, A4, and A5 with severe disease in neonates. We observed a wide capacity in Europe to detect, type, and analyze parechovirus data. To enhance surveillance and response for PeV outbreaks, sharing typing protocols and data on parechovirus-positive cases should be encouraged.
• Subjects:
  Child Child, Preschool Disease Outbreaks Humans Infant, Newborn Laboratories Parechovirus Retrospective Studies
• Keywords:
  Circulation Enteric Infections Epidemiology Meningitis/Encephalitis Parechovirus PeV-A3 PeV-A4 PeV-A5 Seasonality Severity Surveys Viruses

  More +
• Source:
  Emerg Infect Dis. 2024; 30(2):234-244
• Pubmed ID:
  38270192
• Pubmed Central ID:
  PMC10826775
• Document Type:
  Journal Article
• Place as Subject:
  Europe
• Volume:
  30
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8a66ae5881037e828cf44f7beac52dc904f07ab923c37ddc73b13fad682cc2ba
• Download URL:
  https://stacks.cdc.gov/view/cdc/147348/cdc_147348_DS1.pdf
• File Type:
  [PDF - 3.25 MB ]