Laboratory Exposures to Staphylococcal Enterotoxin B

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Rusnak, Janice M. ; Kortepeter, Mark ; Ulrich, Robert ; Poli, Mark ; Boudreau, Ellen
• Description:
  Staphylococcal enterotoxins are 23- to 29-kDa polypeptides in the bacterial superantigen protein family. Clinical symptoms from intoxication with staphylococcal enterotoxins vary by exposure route. Ingestion results in gastrointestinal symptoms, and inhalation results in fever as well as pulmonary and gastrointestinal symptoms. Review of occupational exposures at the U.S. Army Medical Research Institute of Infectious Diseases from 1989 to 2002 showed that three laboratory workers had symptoms after ocular exposure to staphylococcal enterotoxin B (SEB). Conjunctivitis with localized cutaneous swelling occurred in three persons within 1 to 6 hours after exposure to SEB; two of these persons also had gastrointestinal symptoms, which suggests that such symptoms occurred as a result of exposure by an indirect cutaneous or ocular route. Ocular exposures from SEB resulting in conjunctivitis and localized swelling have not previously been reported. Symptoms from these patients and review of clinical symptoms of 16 laboratory-acquired inhalational SEB intoxications may help healthcare workers evaluate and identify SEB exposures in laboratory personnel at risk.
• Subjects:
  Accidents, Occupational Adult Agents Of Bioterrorism Air Pollutants, Occupational Conjunctivitis Cutaneous Symptoms Enterotoxins Eye Diseases Female Gastrointestinal Diseases Gastrointestinal Symptoms Humans Laboratories Laboratory Exposures Male Occupational Exposures Ocular Exposures Staphylococcal Enterotoxin B Synopsis Toxins

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• Source:
  Emerg Infect Dis. 10(9):1544-1549.
• Document Type:
  Journal Article
• Volume:
  10
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a344027ca36aff2e09e31e422b2fbcf8a4b9c95f040083e515ddbd5ae94fb84e
• Download URL:
  https://stacks.cdc.gov/view/cdc/14635/cdc_14635_DS1.pdf
• File Type:
  [PDF - 175.26 KB ]