Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Raymond, Josette ; Thiberge, Jean-Michel ; Chevalier, Catherine ; Kalach, Nicolas ; Bergeret, Michel ; ... More +
Raymond, Josette ; Thiberge, Jean-Michel ; Chevalier, Catherine ; Kalach, Nicolas ; Bergeret, Michel ; Labigne, Agnès ; Dauga, Catherine Less -
Description:
To look for evidence of intrafamilial infection, we isolated 107 Helicobacter pylori clones from biopsied specimens taken from both parents and four children. We compared the sequences of two housekeeping genes (hspA and glmM) from these clones with those of 131 unrelated strains from patients living in different geographic regions. Strain relationships within the family were determined by analyzing allelic variation at both loci and building phylogenetic trees and by using multilocus sequence typing. Both hspA- and glmM-based phylogenetic trees showed East Asian and African branches. All samples from family members showed natural mixed infection. Identical alleles found in some strains isolated from the children and parents, but not in the strains isolated from unrelated patients, demonstrated that strains have circulated within the family. Several mechanisms, such as point mutations, intragenic recombination, and introduction of foreign (African) alleles, were shown to enhance strain diversity within the family.
Subject:
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Adolescent
Adult
Amino Acid Sequence
Bacterial Typing Techniques
Base Sequence
Child
Child, Preschool
Epidemiology
Family Health
Family Transmission
Female
Gastritis
Genes, Bacterial
Genetic Diversity
Genetic Variation
Helicobacter Infections
Helicobacter Pylori
Humans
Male
Molecular Sequence Data
Phylogeny
Research
Sequence Homology, Amino Acid

Source:
Emerg Infect Dis. 10(10):1816-1821.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:49c9e60f89696e5a3ca12f4054e50376dac34227ccad9b8155d609a2f2dce0d6
File Type:

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