Human Herpesviruses 6 and 7 and Central Nervous System Infection in Children1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ansari, Asad ; Li, Shaobing ; Abzug, Mark J. ; Weinberg, Adriana
• Description:
  The role and frequency of human herpesviruses (HHV)-6 and -7 in central nervous system (CNS) diseases of children are unclear. Cerebrospinal fluid samples from 245 pediatric patients (median age 43 days), submitted for evaluations of possible sepsis or of neurologic symptoms, were tested for HHV-6 and HHV-7 DNA by polymerase chain reaction. HHV-6 DNA was found in 3 of 245 samples, and HHV-7 was found in 0 of 245 samples. The three patients with HHV-6 DNA were <2 months of age. HHV-6 was likely pathogenic in two patients with meningitis who lacked evidence of another microbiologic cause. HHV-6 and HHV-7 are uncommon causes of CNS infection in children. HHV-6 may occasionally cause meningitis in young infants.
• Subjects:
  Central Nervous System Viral Diseases Cerebrospinal Fluid Child Child, Preschool Childhood CNS Disorders Childhood Encephalitis Childhood Meningitis DNA, Viral Herpesvirus 6, Human Herpesvirus 7, Human Human Herpesvirus 6 Human Herpesvirus 7 Humans Infant Infant, Newborn Meningitis, Viral Polymerase Chain Reaction Research Roseolovirus Infections

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• Source:
  Emerg Infect Dis. 10(8):1450-1454.
• Document Type:
  Journal Article
• Volume:
  10
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:89e6555c8622c095def7bd184e0499ca48ab74980e828414a8f6d94103d2a80c
• Download URL:
  https://stacks.cdc.gov/view/cdc/14504/cdc_14504_DS1.pdf
• File Type:
  [PDF - 43.15 KB ]