Human Herpesviruses 6 and 7 and Central Nervous System Infection in Children1
Published Date:Aug 2004
Source:Emerg Infect Dis. 10(8):1450-1454.
Keywords:Central Nervous System Viral Diseases
Childhood CNS Disorders
Herpesvirus 6, Human
Herpesvirus 7, Human
Human Herpesvirus 6
Human Herpesvirus 7
Polymerase Chain Reaction
Description:The role and frequency of human herpesviruses (HHV)-6 and -7 in central nervous system (CNS) diseases of children are unclear. Cerebrospinal fluid samples from 245 pediatric patients (median age 43 days), submitted for evaluations of possible sepsis or of neurologic symptoms, were tested for HHV-6 and HHV-7 DNA by polymerase chain reaction. HHV-6 DNA was found in 3 of 245 samples, and HHV-7 was found in 0 of 245 samples. The three patients with HHV-6 DNA were <2 months of age. HHV-6 was likely pathogenic in two patients with meningitis who lacked evidence of another microbiologic cause. HHV-6 and HHV-7 are uncommon causes of CNS infection in children. HHV-6 may occasionally cause meningitis in young infants.
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