Multidrug-resistant Tuberculosis in Central Asia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Cox, Helen Suzanne ; Orozco, Juan Daniel ; Male, Roy ; Ruesch-Gerdes, Sabine ; Falzon, Dennis ; Small, Ian ; Doshetov, Darebay ; Kebede, Yared ; Aziz, Mohammed
• Description:
  Multidrug-resistant tuberculosis (MDR-TB) has emerged as a major threat to TB control, particularly in the former Soviet Union. To determine levels of drug resistance within a directly observed treatment strategy (DOTS) program supported by Médecins Sans Frontières in two regions in Uzbekistan and Turkmenistan, Central Asia, we conducted a cross-sectional survey of smear-positive TB patients in selected districts of Karakalpakstan (Uzbekistan) and Dashoguz (Turkmenistan). High levels of MDR-TB were found in both regions. In Karakalpakstan, 14 (13%) of 106 new patients were infected with MDR-TB; 43 (40%) of 107 previously treated patients were similarly infected. The proportions for Dashoguz were 4% (4/105 patients) and 18% (18/98 patients), respectively. Overall, 27% of patients with positive smear results whose infections were treated through the DOTS program in Karakalpakstan and 11% of similar patients in Dashoguz were infected with multidrug-resistant strains of TB on admission. These results show the need for concerted action by the international community to contain transmission and reduce the effects of MDR-TB.
• Subjects:
  Adolescent Adult Aged Anti-Bacterial Agents Antitubercular Agents Child Drug Resistance, Multiple, Bacterial Female Humans Male Microbial Sensitivity Tests Middle Aged Mycobacterium Tuberculosis Sputum Tuberculosis, Multidrug-Resistant

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• Source:
  Emerg Infect Dis. 10(5):865-872.
• Document Type:
  Journal Article
• Place as Subject:
  Asia, Central ; Uzbekistan ; Turkmenistan
• Location:
  Asia
• Volume:
  10
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:5db3ba78c97c56805ea998fe594407914800f8dfd29f47385cb9455c01d9a34c
• Download URL:
  https://stacks.cdc.gov/view/cdc/14489/cdc_14489_DS1.pdf
• File Type:
  [PDF - 294.05 KB ]