Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Johnson, Michael A.S. ; Smith, Hannah ; Joseph, Priya ; Gilman, Robert H. ; Bautista, Christian T. ; ... More +
Johnson, Michael A.S. ; Smith, Hannah ; Joseph, Priya ; Gilman, Robert H. ; Bautista, Christian T. ; Campos, Kalina J. ; Cespedes, Michelle ; Klatsky, Peter ; Vidal, Carlos ; Terry, Hilja ; Calderon, Maritza M. ; Coral, Carlos ; Cabrera, Lilia ; Parmar, Paminder S. ; Vinetz, Joseph M. ; Less -
Description:
Human infection by leptospires has highly variable clinical manifestations, which range from subclinical infection to fulminant disease. We conducted a population-based, cross-sectional seroepidemiologic study in Peru to determine potential relationships of environmental context to human exposure to Leptospira and disease associated with seroconversion. Three areas were studied: a flooded, urban slum in the Peruvian Amazon city of Iquitos; rural, peri-Iquitos villages; and a desert shantytown near Lima. Seroprevalence in Belen was 28% (182/650); in rural areas, 17% (52/316); and in a desert shantytown, 0.7% (1/150). Leptospira-infected peridomestic rats were found in all locales. In Belen, 20 (12.4%) of 161 patients seroconverted between dry and wet seasons (an incidence rate of 288/1,000). Seroconversion was associated with history of febrile illness; severe leptospirosis was not seen. Human exposure to Leptospira in the Iquitos region is high, likely related both to the ubiquity of leptospires in the environment and human behavior conducive to transmission from infected zoonotic sources.
Subject:
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Adolescent
Adult
Aged
Animals
Antibodies, Protozoan
Child
Child, Preschool
DNA, Protozoan
Environmental Exposure
Enzyme-Linked Immunosorbent Assay
Female
Humans
Infant
Leptospira
Male
Middle Aged
Polymerase Chain Reaction
Poverty
Rats
Seroepidemiologic Studies
Tropical Climate

Source:
Emerg Infect Dis. 10(6):1016-1022. ;
Document Type:
Journal Article ;
Place as Subject:
Peru ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:78193e58632d052e122de8fe56cc5e0acba72545243f4fba11d49486ff0add7a
File Type:

Supporting Files

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