Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Wang, Jann-Tay ; Sheng, Wang-Huei ; Fang, Chi-Tai ; Chen, Yee-Chun ; Wang, Jiun-Ling ; Yu, Chong-Jen ; Chang, Shan-Chwen ; Yang, Pan-Chyr
• Description:
  Clinical and laboratory data on severe acute respiratory syndrome (SARS), particularly on the temporal progression of abnormal laboratory findings, are limited. We conducted a prospective study on the clinical, radiologic, and hematologic findings of SARS patients with pneumonia, who were admitted to National Taiwan University Hospital from March 8 to June 15, 2003. Fever was the most frequent initial symptom, followed by cough, myalgia, dyspnea, and diarrhea. Twenty-four patients had various underlying diseases. Most patients had elevated C-reactive protein (CRP) levels and lymphopenia. Other common abnormal laboratory findings included leukopenia, thrombocytopenia, and elevated levels of aminotransferase, lactate dehydrogenase, and creatine kinase. These clinical and laboratory findings were exacerbated in most patients during the second week of disease. The overall case-fatality rate was 19.7%. By multivariate analysis, underlying disease and initial CRP level were predictive of death.
• Subjects:
  Adult Aged Aged, 80 And Over C-reactive Protein Clinical Laboratory Techniques Communicable Diseases, Emerging Disease Outbreaks Female Hospitalization Humans Intravenous Immunoglobulin Male Middle Aged Prospective Studies Research SARS Virus Severe Acute Respiratory Syndrome Taiwan Treatment Outcome

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• Source:
  Emerg Infect Dis. 10(5):818-824.
• Document Type:
  Journal Article
• Volume:
  10
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f828011cebaec420aec391368b8e68df0cf155a2690655af9e3bb2825d13a392
• Download URL:
  https://stacks.cdc.gov/view/cdc/14464/cdc_14464_DS1.pdf
• File Type:
  [PDF - 64.51 KB ]