Endemic Venezuelan Equine Encephalitis in Northern Peru

Aguilar, Patricia V.; Greene, Ivorlyne P.; Coffey, Lark L.; Medina, Gladys; Moncayo, Abelardo C.; Anishchenko, Michael; Ludwig, George V.; Turell, Michael J.; O’Guinn, Monica L.; Lee, John; Tesh, Robert B.; Watts, Douglas M.; Russell, Kevin L.; Hice, Christine; Yanoviak, Stephen; Morrison, Amy C.; Klein, Terry A.; Dohm, David J.; Guzman, Hilda; Travassos da Rosa, Amelia P.A.; Guevara, Carolina; Kochel, Tadeusz; Olson, James; Cabezas, Cesar; Weaver, Scott C.

doi:10.3201/eid1005.030634

i

Endemic Venezuelan Equine Encephalitis in Northern Peru

Supporting Files

May 2004
By Aguilar, Patricia V. ; Greene, Ivorlyne P. ; Coffey, Lark L. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Aguilar, Patricia V. ; Greene, Ivorlyne P. ; Coffey, Lark L. ; Medina, Gladys ; Moncayo, Abelardo C. ; Anishchenko, Michael ; Ludwig, George V. ; Turell, Michael J. ; O’Guinn, Monica L. ; Lee, John ; Tesh, Robert B. ; Watts, Douglas M. ; Russell, Kevin L. ; Hice, Christine ; Yanoviak, Stephen ; Morrison, Amy C. ; Klein, Terry A. ; Dohm, David J. ; Guzman, Hilda ; Travassos da Rosa, Amelia P.A. ; Guevara, Carolina ; Kochel, Tadeusz ; Olson, James ; Cabezas, Cesar ; Weaver, Scott C.
Description:

Since Venezuelan equine encephalitis virus (VEEV) was isolated in Peru in 1942, >70 isolates have been obtained from mosquitoes, humans, and sylvatic mammals primarily in the Amazon region. To investigate genetic relationships among the Peru VEEV isolates and between the Peru isolates and other VEEV strains, a fragment of the PE2 gene was amplified and analyzed by single-stranded conformation polymorphism. Representatives of seven genotypes underwent sequencing and phylogenetic analysis. The results identified four VEE complex lineages that cocirculate in the Amazon region: subtypes ID (Panama and Colombia/Venezuela genotypes), IIIC, and a new, proposed subtype IIID, which was isolated from a febrile human, mosquitoes, and spiny rats. Both ID lineages and the IIID subtype are associated with febrile human illness. Most of the subtype ID isolates belonged to the Panama genotype, but the Colombia/Venezuela genotype, which is phylogenetically related to epizootic strains, also continues to circulate in the Amazon basin.
Subjects:

Animals Culicidae Encephalitis Virus, Venezuelan Equine Encephalomyelitis, Venezuelan Equine Endemic Diseases Genotype Humans Membrane Glycoproteins Phylogeny Polymorphism, Single-Stranded Conformational Protein Precursors Rna, Viral Rodent Diseases Rodentia Sequence Analysis, DNA Viral Proteins
Source:

Emerg Infect Dis. 10(5):880-888.
Document Type:

Journal Article
Funding:

AI49725-01/AI/NIAID NIH HHS/United States
Place as Subject:

Peru
Volume:

10
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:e08dc96a7370709ec945352cbfd35e15d968b7dd2fe57c83590254666276c2b3
Download URL:

https://stacks.cdc.gov/view/cdc/14462/cdc_14462_DS1.pdf
File Type:

[PDF - 480.28 KB ]

File Language:

English

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