Fluoroquinolone and Other Antimicrobial Resistance in Invasive Pneumococci, Hong Kong, 1995–2001

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ho, Pak-Leung ; Que, Tak-Lun ; Chiu, Susan S. ; Yung, Raymond W. H. ; Ng, Tak-Keung ; Tsang, Dominic N.C. ; Seto, Wing-Hong ; Lau, Yu-Lung
• Description:
  We determined the susceptibilities of 265 invasive isolates of pneumococci obtained during 1995 to 2001 in Hong Kong to 11 antimicrobial agents and their serotypes. Overall, 62.6% isolates were susceptible to penicillin, 20% were intermediately resistant, and 17.4% were resistant. The overall prevalence of levofloxacin resistance (MIC > or = 8 microg/mL) was 3.8% but increased to 15.2% among the penicillin-resistant isolates. All levofloxacin-resistant isolates were clonally related; had reduced susceptibility to penicillin, cefotaxime, and clarithromycin; and were derived from adults > or = 50 years of age. Of the penicillin-nonsusceptible pneumococci, 90% from children < or = 5 years of age and 54.8% from persons of all ages were of serotypes that are included in the 7-valent pneumococcal conjugate vaccine; 93.5% from children < or = 5 years of age and 93% from persons of all ages were of serotypes that are included in the 23-valent polysaccharide vaccine.
• Subjects:
  • Research
  • Streptococcus Pneumoniae
  • Drug Resistance
  • Microbial
  • Anti-Infective Agents
  • Fluoroquinolone
  • Multilocus Sequence Typing
  • Adolescent
  • Adult
  • Anti-Bacterial Agents
  More +
• Source:
  Emerg Infect Dis. 10(7):1250-1257.
• Document Type:
  Journal Article
• Volume:
  10
• Issue:
  7
• Download URL:
  https://stacks.cdc.gov/view/cdc/14453/cdc_14453_DS1.pdf
• File Type:
  [PDF - 236.14 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f2aaf1577612ea7dcecb2228cf2d2efd3d8cc9e06dfbeefca06f6b9e4bb84af3