Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Chan, Kwok H. ; Poon, Leo L.L.M. ; Cheng, V.C.C. ; Guan, Yi ; Hung, I.F.N. ; ... More +
Chan, Kwok H. ; Poon, Leo L.L.M. ; Cheng, V.C.C. ; Guan, Yi ; Hung, I.F.N. ; Kong, James ; Yam, Loretta Y.C. ; Seto, Wing H. ; Yuen, Kwok Y. ; Peiris, Joseph S. Malik Less -
Description:
Cases of severe acute respiratory syndrome (SARS) were investigated for SARS coronavirus (SARS-CoV) through RNA tests, serologic response, and viral culture. Of 537 specimens from patients in whom SARS was clinically diagnosed, 332 (60%) had SARS-CoV RNA in one or more clinical specimens, compared with 1 (0.3%) of 332 samples from controls. Of 417 patients with clinical SARS from whom paired serum samples were available, 92% had an antibody response. Rates of viral RNA positivity increased progressively and peaked at day 11 after onset of illness. Although viral RNA remained detectable in respiratory secretions and stool and urine specimens for >30 days in some patients, virus could not be cultured after week 3 of illness. Nasopharyngeal aspirates, throat swabs, or sputum samples were the most useful clinical specimens in the first 5 days of illness, but later in the illness viral RNA could be detected more readily in stool specimens.
Subject:
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Antibodies, Viral
Diagnosis
Epidemiology
Humans
Pathogenesis
Research
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral
SARS
SARS Coronavirus
SARS Virus
Severe Acute Respiratory Syndrome
Time Factors
Transmission
Virus

Source:
Emerg Infect Dis. 10(2):294-299.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:e30fb7ccacbe786f93f687fefbab5a59cbd8c60773fbb1c234561efbfffd733e
File Type:

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