Virulence Factors for Hemolytic Uremic Syndrome, Denmark1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ethelberg, Steen ; Olsen, Katharina E. P. ; Scheutz, Flemming ; Jensen, Charlotte ; Schiellerup, Peter ; Engberg, Jørgen ; Petersen, Andreas Munk ; Olesen, Bente ; Gerner-Smidt, Peter ; Mølbak, Kåre
• Description:
  We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx2 genes, O groups O157 and O103, and increasing age. Risk factors for HUS were presence of the stx2 (odds ratio OR 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than the O group, the combined presence of the eae and stx2 genes is an important predictor of HUS.
• Subjects:
  • Research
  • Escherichia coli O157
  • Verocytotoxin
  • Stx Protein
  • Antibiotics
  • Cohort Analysis
  • Virulence Factor
  • Epidemiology
  • Serotype
  • Adhesins, Bacterial
  More +
• Source:
  Emerg Infect Dis. 10(5):842-847.
• Document Type:
  Journal Article
• Volume:
  10
• Issue:
  5
• Download URL:
  https://stacks.cdc.gov/view/cdc/14442/cdc_14442_DS1.pdf
• File Type:
  [PDF - 57.45 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:bd39f36cfda17be43da73d0685eb2a4b01f8e9ba18cec08dfb81e601db68399a