Vancomycin Susceptibility within Methicillin-resistant Staphylococcus aureus Lineages

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Howe, Robin A. ; Monk, Alastair ; Wootton, Mandy ; Walsh, Timothy R. ; Enright, Mark C.
• Description:
  Methicillin-resistant Staphylococcus aureus (MRSA) with reduced vancomycin susceptibility vancomycin-intermediate S. aureus (VISA) has been reported from many countries. Whether resistance is evolving regularly in different genetic backgrounds or in a single clone with a genetic predisposition, as early results suggest, is unclear. We have studied 101 MRSA with reduced vancomycin susceptibility from nine countries by multilocus sequence typing (MLST), characterization of SCCmec (staphylococcal chromosomal cassette mec), and agr (accessory gene regulator). We found nine genotypes by MLST, with isolates within all five major hospital MRSA lineages. Most isolates (88/101) belonged to two of the earliest MRSA clones that have global prevalence. Our results show that reduced susceptibility to vancomycin has emerged in many successful epidemic lineages with no clear clonal disposition. Increasing antimicrobial resistance in genetically distinct pandemic clones may lead to MRSA infections that will become increasingly difficult to treat.
• Subjects:
  Anti-Bacterial Agents Bacterial Proteins Bacterial Typing Techniques Drug Resistance, Bacterial Evolution, Molecular Humans Methicillin Resistance Microbial Sensitivity Tests Research Sequence Analysis, DNA Staphylococcal Infections Staphylococcus Aureus Staphylococcus Aureus Epidemiology Trans-Activators Vancomycin

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• Source:
  Emerg Infect Dis. 10(5):855-857.
• Document Type:
  Journal Article
• Volume:
  10
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:7b09723d0c41d249e10355f7b0e2614a02227a76dddecbf8cf354dce2546c34f
• Download URL:
  https://stacks.cdc.gov/view/cdc/14433/cdc_14433_DS1.pdf
• File Type:
  [PDF - 46.55 KB ]