Severe Acute Respiratory Syndrome: Clinical Outcome and Prognostic Correlates1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Tsui, Ping Tim ; Kwok, Man Leung ; Yuen, Hon ; Lai, Sik To
• Description:
  Severe acute respiratory syndrome (SARS) poses a major threat to the health of people worldwide. We performed a retrospective case series analysis to assess clinical outcome and identify pretreatment prognostic correlates of SARS, managed under a standardized treatment protocol. We studied 127 male and 196 female patients with a mean age of 41+14 (range 18-83). All patients, except two, received ribavirin and steroid combination therapy. In 115 (36%) patients, the course of disease was limited. Pneumonitis progressed rapidly in the remaining patients. Sixty-seven (21%) patients required intensive care, and 42 (13%) required ventilator support. Advanced age, high admission neutrophil count, and high initial lactate dehydrogenase level were independent correlates of an adverse clinical outcome. SARS-associated coronavirus caused severe illnesses in most patients, despite early treatment with ribavirin and steroid. This study has identified three independent pretreatment prognostic correlates.
• Subjects:
  Adult Aged Aged, 80 And Over Antiviral Agents Clinical Outcome Communicable Diseases, Emerging Female Humans Male Middle Aged Pneumonia Prognosis Research Respiration, Artificial Retrospective Studies Ribavirin Severe Acute Respiratory Syndrome Steroid Treatment Outcome

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• Source:
  Emerg Infect Dis. 9(9):1064-1069.
• Document Type:
  Journal Article
• Volume:
  9
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b12fea834907f5b81ca869da8524ef75104c19fdd2a3a20cb2666aa26b579446
• Download URL:
  https://stacks.cdc.gov/view/cdc/14355/cdc_14355_DS1.pdf
• File Type:
  [PDF - 281.44 KB ]