Severe Acute Respiratory Syndrome: Clinical Outcome and Prognostic Correlates1

Tsui, Ping Tim; Kwok, Man Leung; Yuen, Hon; Lai, Sik To

doi:10.3201/eid0909.030362

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Severe Acute Respiratory Syndrome: Clinical Outcome and Prognostic Correlates1

Published Date:

Sep 2003

Publisher's site:

http://dx.doi.org/10.3201/eid0909.030362 New Site Icon

Source:

Emerg Infect Dis. 9(9):1064-1069.

[PDF-281.44 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Tsui, Ping Tim ; Kwok, Man Leung ; Yuen, Hon ; Lai, Sik To ;

Description:

Severe acute respiratory syndrome (SARS) poses a major threat to the health of people worldwide. We performed a retrospective case series analysis to assess clinical outcome and identify pretreatment prognostic correlates of SARS, managed under a standardized treatment protocol. We studied 127 male and 196 female patients with a mean age of 41+14 (range 18-83). All patients, except two, received ribavirin and steroid combination therapy. In 115 (36%) patients, the course of disease was limited. Pneumonitis progressed rapidly in the remaining patients. Sixty-seven (21%) patients required intensive care, and 42 (13%) required ventilator support. Advanced age, high admission neutrophil count, and high initial lactate dehydrogenase level were independent correlates of an adverse clinical outcome. SARS-associated coronavirus caused severe illnesses in most patients, despite early treatment with ribavirin and steroid. This study has identified three independent pretreatment prognostic correlates.

Subject:

[+]

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

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Supporting Files:

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