Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in Salmonella enterica Typhimurium Isolates in Humans

Casin, Isabelle; Breuil, Jacques; Darchis, Jean Pierre; Guelpa, Claire; Collatz, Ekkehard

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Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in Salmonella enterica Typhimurium Isolates in Humans

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Nov 2003
By Casin, Isabelle ; Breuil, Jacques ; Darchis, Jean Pierre ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Casin, Isabelle ; Breuil, Jacques ; Darchis, Jean Pierre ; Guelpa, Claire ; Collatz, Ekkehard
Description:

We report two cases of infection with clonally unrelated, high-level ciprofloxacin-resistant, β-lactamase–producing strains of | Typhimurium. Resistance was caused by four topoisomerase mutations, in GyrA, GyrB, and ParC and increased drug efflux. Ciprofloxacin treatment failed in one case. In the second case, reduced susceptibility to third-generation cephalosporins occurred after initial treatment with these drugs and may explain the treatment failure with ceftriaxone.
Subjects:

Dispatch
Source:

Emerg Infect Dis. 9(11):1482-1483.
Document Type:

Journal Article
Volume:

9
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:652c22bc0bc6742d2c858fdf94f38c5bfbb9eebd4a8d36c26c3e5540539d323c
Download URL:

https://stacks.cdc.gov/view/cdc/14337/cdc_14337_DS1.pdf
File Type:

[PDF - 212.21 KB ]

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