Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in Salmonella enterica Typhimurium Isolates in Humans

Casin, Isabelle; Breuil, Jacques; Darchis, Jean Pierre; Guelpa, Claire; Collatz, Ekkehard

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Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in Salmonella enterica Typhimurium Isolates in Humans

Nov 2003
By Casin, Isabelle ; Breuil, Jacques ; Darchis, Jean Pierre ; ...
Source: Emerg Infect Dis. 9(11):1482-1483.

[PDF-212.21 KB]

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Alternative Title:

Emerg Infect Dis
Personal Author:

Casin, Isabelle ; Breuil, Jacques ; Darchis, Jean Pierre ; Guelpa, Claire ; Collatz, Ekkehard

Casin, Isabelle ; Breuil, Jacques ; Darchis, Jean Pierre ; Guelpa, Claire ; Collatz, Ekkehard Less -
Description:

We report two cases of infection with clonally unrelated, high-level ciprofloxacin-resistant, β-lactamase–producing strains of | Typhimurium. Resistance was caused by four topoisomerase mutations, in GyrA, GyrB, and ParC and increased drug efflux. Ciprofloxacin treatment failed in one case. In the second case, reduced susceptibility to third-generation cephalosporins occurred after initial treatment with these drugs and may explain the treatment failure with ceftriaxone.
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Source:

Emerg Infect Dis. 9(11):1482-1483.
Document Type:

Journal Article
Collection(s):

Emerging Infectious Diseases
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urn:sha256:652c22bc0bc6742d2c858fdf94f38c5bfbb9eebd4a8d36c26c3e5540539d323c
Download URL:

https://stacks.cdc.gov/view/cdc/14337/cdc_14337_DS1.pdf
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	03-0317.nxml	txt
	license.txt	txt

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