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Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in Salmonella enterica Typhimurium Isolates in Humans

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  • Alternative Title:
    Emerg Infect Dis
  • Personal Author:
    Casin, Isabelle ; Breuil, Jacques ; Darchis, Jean Pierre ; Guelpa, Claire ; Collatz, Ekkehard
  • Description:
    We report two cases of infection with clonally unrelated, high-level ciprofloxacin-resistant, β-lactamase–producing strains of | Typhimurium. Resistance was caused by four topoisomerase mutations, in GyrA, GyrB, and ParC and increased drug efflux. Ciprofloxacin treatment failed in one case. In the second case, reduced susceptibility to third-generation cephalosporins occurred after initial treatment with these drugs and may explain the treatment failure with ceftriaxone.
  • Subjects:
  • Source:
    Emerg Infect Dis. 9(11):1482-1483.
  • Document Type:
    Journal Article
  • Volume:
    9
  • Issue:
    11
  • Download URL:
    https://stacks.cdc.gov/view/cdc/14337/cdc_14337_DS1.pdf
  • File Type:
    Filetype[PDF - 212.21 KB]
  • Collection(s):
    Emerging Infectious Diseases
  • Main Document Checksum:
    urn:sha256:652c22bc0bc6742d2c858fdf94f38c5bfbb9eebd4a8d36c26c3e5540539d323c
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