Fluoroquinolones and the Risk for Methicillin-resistant Staphylococcus aureus in Hospitalized Patients1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Weber, Stephen G. ; Gold, Howard S. ; Hooper, David C. ; Karchmer, A.W. ; Carmeli, Yehuda
• Description:
  To determine whether fluoroquinolone exposure is a risk factor for the isolation of Staphylococcus aureus and whether the effect is different for methicillin-resistant S. aureus (MRSA) versus methicillin--susceptible S. aureus (MSSA), we studied two case groups. The first case group included 222 patients with nosocomially acquired MRSA. The second case group included 163 patients with nosocomially acquired MSSA. A total of 343 patients admitted concurrently served as controls. Outcome measures were the adjusted odds ratio (OR) for isolation of MRSA and MSSA after fluoroquinolone exposure. Exposure to both levofloxacin (OR 5.4; p <0.0001) and ciprofloxacin (OR 2.2; p < 0.003) was associated with isolation of MRSA but not MSSA. After adjustment for multiple variables, both drugs remained risk factors for MRSA (levofloxacin OR 3.4; p <0.0001; ciprofloxacin OR 2.5; p = 0.005) but not MSSA. Exposure to levofloxacin or ciprofloxacin is a significant risk factor for the isolation of MRSA, but not MSSA.
• Subjects:
  Aged Anti-Infective Agents Case-Control Studies Ciprofloxacin Cross Infection Female Fluoroquinolones Humans Male Methicillin Resistance Middle Aged Research Risk Factors Staphylococcus Aureus

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• Source:
  Emerg Infect Dis. 9(11):1415-1422.
• Document Type:
  Journal Article
• Volume:
  9
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8b2c67f28085672221009165276bfebfab0f62d2136daecd1cc6646a05fe114d
• Download URL:
  https://stacks.cdc.gov/view/cdc/14325/cdc_14325_DS1.pdf
• File Type:
  [PDF - 258.93 KB ]