Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid0912.030276
Personal Author:
Lillebaek, Troels ; Andersen, Åse B. ; Dirksen, Asger ; Glynn, Judith R. ; Kremer, Kristin
Lillebaek, Troels ; Andersen, Åse B. ; Dirksen, Asger ; Glynn, Judith R. ; Kremer, Kristin Less -
Description:
Molecular epidemiologic studies of strains of Mycobacterium tuberculosis are currently conducted worldwide. The genetically distinct Beijing family of strains has been associated with large outbreaks of tuberculosis, increased virulence, and multidrug resistance. However, in this first population-based search for Beijing strains in the Danish DNA fingerprint database, analysis of 97% of all culture-positive tuberculosis patients in 1992 to 2001 showed that 2.5% of 3,844 patients, 1.0% of Danish-born patients, and 3.6% of immigrants (from 85 countries) had Beijing strains. No Beijing strains were found among 201 strains from Danish-born patients sampled in the 1960s, and no evidence of an increase in Beijing strains was found over time. The true prevalence of Beijing strains worldwide is unknown because only a fraction of global strains have been analyzed.
Subject:
[+]
Adult
Aged
Beijing Family
Denmark
DNA, Bacterial
DNA Fingerprinting
Female
Genetic Variation
Genotype
Humans
IS6110 RFLP
Male
Middle Aged
Molecular Epidemiology
Mycobacterium Tuberculosis
Polymorphism, Restriction Fragment Length
Prevalence
Research
Tuberculosis
W-strain

Source:
Emerg Infect Dis. 9(12):1553-1557.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:6d3f74e05c52b9019b4ff873f265ef06445ac432d870e72fadf60fbe1647ff8c
File Type:

Supporting Files

• 	03-0276.nxml	txt
  	license.txt	txt

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