Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Linke, Michael J. ; Rebholz, Sandy ; Collins, Margaret ; Tanaka, Reiko ; Cushion, Melanie T.
• Description:
  The progression of Pneumocystis carinii pneumonia was temporally monitored and quantified by real-time polymerase chain reaction of P. carinii-specific DNA in oral swabs and lung homogenates from infected rats. DNA levels correlated with the number of P. carinii organisms in the rats' lungs, as enumerated by microscopic methods. This report is the first of a noninvasive, antemortem method that can be used to monitor infection in a host over time.
• Subjects:
  Animals Bronchoalveolar Lavage Dispatch DNA, Fungal DNA, Mitochondrial Fungal Immunocompromised Host Lung Lung Diseases Male Mouth Mucosa Pneumocystis Carinii Pneumonia Pneumonia, Pneumocystis Polymerase Chain Reaction Rats Rats, Long-Evans Statistics, Nonparametric

  More +
• Source:
  Emerg Infect Dis. 9(12):1613-1616.
• Document Type:
  Journal Article
• Funding:
  R01 AI29839-10/AI/NIAID NIH HHS/United States
• Volume:
  9
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a70437a8698f3280f81fedd3bdbdd369160be18735264e48c6ea1ae6fb2d14f4
• Download URL:
  https://stacks.cdc.gov/view/cdc/14318/cdc_14318_DS1.pdf
• File Type:
  [PDF - 409.65 KB ]