Welcome to CDC stacks |
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Fungal Biofilms and Drug Resistance
Filetype[PDF-170.41 KB]


Details:
  • Alternative Title:
    Emerg Infect Dis
  • Personal Author:
  • Description:
    Candida species, including the novel opportunistic pathogen Candida dubliniensis, are now emerging as major agents of nosocomial infections. Many such manifestations of infections associated with the formation of Candida biofilms include those occurring on devices such as indwelling intravascular catheters. Fungal biofilm-associated infections are frequently refractory to conventional therapy because of resistance to antimicrobial agents. This resistance could be in part due to the surface-induced upregulation of drug efflux pumps. Biofilm-associated Candida show uniform resistance to a wide spectrum of the currently available conventional antifungal agents, which implies that antimicrobial drugs that specifically target biofilm-associated infections are needed. The novel classes of antifungal agents, the lipid formulation of amphotericins, and the echinocandins have demonstrated unique antifungal activity against the resistant Candida biofilms, providing a breakthrough in the treatment of life-threatening invasive systemic mycoses. The use of drugs effective in combating biofilm-associated infections could lead to major developments in the treatment of fungal implant infections.

  • Subject:
  • Document Type:
    Journal Article
  • Collection(s):
    Emerging Infectious Diseases
  • Main Document Checksum:
No Related Documents.
You May Also Like:
  1. Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms
    Personal Author:
    Van Dijck, Patrick; Sjollema, Jelmer; Cammue, Bruno P. A.; Lagrou, Katrien; Berman, Judith; d’Enfert, Christophe; Andes, David R.; Arendrup, Maiken C.; Brakhage, Axel A.; Calderone, Richard; Cantón, Emilia; Coenye, Tom; Cos, Paul; Cowen, Leah E.; Edgerton, Mira; Espinel-Ingroff, Ana; Filler, Scott G.; Ghannoum, Mahmoud; Gow, Neil A.R.; Haas, Hubertus; Jabra-Rizk, Mary Ann; Johnson, Elizabeth M.; Lockhart, Shawn R.; Lopez-Ribot, Jose L.; Maertens, Johan; Munro, Carol A.; Nett, Jeniel E.; Nobile, Clarissa J.; Pfaller, Michael A.; Ramage, Gordon; Sanglard, Dominique; Sanguinetti, Maurizio; Spriet, Isabel; Verweij, Paul E.; Warris, Adilia; Wauters, Joost; Yeaman, Michael R.; Zaat, Sebastian A.J.; Thevissen, Karin;
    Published Date:
    Jun 14 2018
    Source:
    Microb Cell. 2018; 5(7):300-326.
    Description:
    Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical...
    File Type:
    Filetype[PDF - 948.31 KB]
  2. Biofilm on Ventriculo-Peritoneal Shunt Tubing as a Cause of Treatment Failure in Coccidioidal Meningitis
    Personal Author:
    Davis, Larry E.; Cook, Guy; Costerton, J. William;
    Published Date:
    Apr 2002
    Source:
    Emerg Infect Dis. 8(4):376-379.
    Description:
    We describe a case of recurrent coccidioidal meningitis in which a fungal biofilm on the tip of ventriculo-peritoneal shunt tubing was likely responsible for a 4-year persistence of Coccidioides immitis, despite the patient's taking an adequate dosag...
    File Type:
    Filetype[PDF - 4.22 MB]
  3. Biofilm-Forming Capability of Highly Virulent, Multidrug-Resistant Candida auris
    Personal Author:
    Sherry, Leighann; Ramage, Gordon; Kean, Ryan; Borman, Andrew; Johnson, Elizabeth M.; Richardson, Malcolm D.; Rautemaa-Richardson, Riina;
    Published Date:
    Feb 2017
    Source:
    Emerg Infect Dis. 23(2):328-331.
    Description:
    The emerging multidrug-resistant yeast pathogen Candida auris has attracted considerable attention as a source of healthcare-associated infections. We report that this highly virulent yeast has the capacity to form antifungal resistant biofilms sensi...
    File Type:
    Filetype[PDF - 1.03 MB]
  4. Biofilms and device-associated infections.
    Personal Author:
    Donlan, R. M.
    Published Date:
    2001 Mar-Apr
    Source:
    Emerg Infect Dis. 7(2):277-281.
    Description:
    Microorganisms commonly attach to living and nonliving surfaces, including those of indwelling medical devices, and form biofilms made up of extracellular polymers. In this state, microorganisms are highly resistant to antimicrobial treatment and are...
    File Type:
    Filetype[PDF - 115.53 KB]
  5. Candida auris in South Africa, 2012–2016
    Personal Author:
    Govender, Nelesh P.; Magobo, Rindidzani E.; Mpembe, Ruth; Mhlanga, Mabatho; Matlapeng, Phelly; Corcoran, Craig; Govind, Chetna; Lowman, Warren; Senekal, Marthinus; Thomas, Juno;
    Published Date:
    November 2018
    Source:
    Emerg Infect Dis. 24(11):2036-2040
    Description:
    To determine the epidemiology of Candida auris in South Africa, we reviewed data from public- and private-sector diagnostic laboratories that reported confirmed and probable cases of invasive disease and colonization for October 2012-November 2016. W...
    File Type:
    Filetype[PDF - 809.29 KB]