Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1001.030119
Personal Author:
Jabra-Rizk, Mary Ann ; Falkler, William A. ; Meiller, Timothy F. ;
Jabra-Rizk, Mary Ann ; Falkler, William A. ; Meiller, Timothy F. ; Less -
Description:
Candida species, including the novel opportunistic pathogen Candida dubliniensis, are now emerging as major agents of nosocomial infections. Many such manifestations of infections associated with the formation of Candida biofilms include those occurring on devices such as indwelling intravascular catheters. Fungal biofilm-associated infections are frequently refractory to conventional therapy because of resistance to antimicrobial agents. This resistance could be in part due to the surface-induced upregulation of drug efflux pumps. Biofilm-associated Candida show uniform resistance to a wide spectrum of the currently available conventional antifungal agents, which implies that antimicrobial drugs that specifically target biofilm-associated infections are needed. The novel classes of antifungal agents, the lipid formulation of amphotericins, and the echinocandins have demonstrated unique antifungal activity against the resistant Candida biofilms, providing a breakthrough in the treatment of life-threatening invasive systemic mycoses. The use of drugs effective in combating biofilm-associated infections could lead to major developments in the treatment of fungal implant infections.
Subject:
[+]
Antifungal Agents
Antifungal Drug Resistance
Biofilms
Candida
Candida Albicans
Candida Dubliniensis
Drug Resistance
Echinocandins
Fungi
Synopsis
Biofilms

Source:
Emerg Infect Dis. 10(1):14-19. ;
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:8c3ac3ee4430f0783af1ae30de51c3d77ca6ec86c1947414aad6aa6d786c2ec7
File Type:

Supporting Files

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  	03-0119_FinalS.nxml	txt
  	license.txt	txt

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