NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America1

Pottumarthy, Sudha; Moland, Ellen Smith; Juretschko, Stefan; Swanzy, Susan R.; Thomson, Kenneth S.; Fritsche, Thomas R.

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America1

Aug 2003
By Pottumarthy, Sudha ; Moland, Ellen Smith ; Juretschko, Stefan ; ...
Source: Emerg Infect Dis. 9(8):999-1002

[PDF-298.36 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Pottumarthy, Sudha ; Moland, Ellen Smith ; Juretschko, Stefan ; Swanzy, Susan R. ; Thomson, Kenneth S. ; ... More +

Pottumarthy, Sudha ; Moland, Ellen Smith ; Juretschko, Stefan ; Swanzy, Susan R. ; Thomson, Kenneth S. ; Fritsche, Thomas R. Less -
Description:

An imipenem-resistant Enterobacter cloacae isolate was recovered from the blood of a patient with a hematologic malignancy. Analytical isoelectric focusing, inhibitor studies, hydrolysis, induction assays, and molecular sequencing methods confirmed the presence of a NmcA carbapenem-hydrolyzing enzyme. This first report of NmcA detected in North America warrants further investigation into its distribution and clinical impact.
Subjects:

[+]

Adult Antibiotic Resistance Bacterial Proteins Beta-lactamase Beta-Lactamases Carbapenem Dispatch Drug Resistance, Microbial Enterobacter Cloacae Humans Imipenem Isoelectric Focusing Leukemia, Myeloid Male Microbial Sensitivity Tests
Source:

Emerg Infect Dis. 9(8):999-1002
Pubmed ID:

12967501
Pubmed Central ID:

PMC3020613
Document Type:

Journal Article
Volume:

9
Issue:

8
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:c7d50f7af35a88b48a9caa61171f5d6b7f767c432d5349a3210b7811e1592f75
Download URL:

https://stacks.cdc.gov/view/cdc/14258/cdc_14258_DS1.pdf
File Type:

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