NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Pottumarthy, Sudha ; Moland, Ellen Smith ; Juretschko, Stefan ; Swanzy, Susan R. ; Thomson, Kenneth S. ; Fritsche, Thomas R.
• Description:
  An imipenem-resistant Enterobacter cloacae isolate was recovered from the blood of a patient with a hematologic malignancy. Analytical isoelectric focusing, inhibitor studies, hydrolysis, induction assays, and molecular sequencing methods confirmed the presence of a NmcA carbapenem-hydrolyzing enzyme. This first report of NmcA detected in North America warrants further investigation into its distribution and clinical impact.
• Subjects:
  Adult Antibiotic Resistance Bacterial Proteins Beta-lactamase Beta-Lactamases Carbapenem Dispatch Drug Resistance, Microbial Enterobacter Cloacae Humans Imipenem Isoelectric Focusing Leukemia, Myeloid Male Microbial Sensitivity Tests

  More +
• Source:
  Emerg Infect Dis. 9(8):999-1002
• Pubmed ID:
  12967501
• Pubmed Central ID:
  PMC3020613
• Document Type:
  Journal Article
• Volume:
  9
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:c7d50f7af35a88b48a9caa61171f5d6b7f767c432d5349a3210b7811e1592f75
• Download URL:
  https://stacks.cdc.gov/view/cdc/14258/cdc_14258_DS1.pdf
• File Type:
  [PDF - 298.36 KB ]