Enzootic Transmission of Yellow Fever Virus in Peru

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bryant, Juliet ; Wang, Heiman ; Cabezas, Cesar ; Ramirez, Gladys ; Watts, Douglas ; Russell, Kevin ; Barrett, Alan
• Description:
  The prevailing paradigm of yellow fever virus (YFV) ecology in South America is that of wandering epizootics. The virus is believed to move from place to place in epizootic waves involving monkeys and mosquitoes, rather than persistently circulating within particular locales. After a large outbreak of YFV illness in Peru in 1995, we used phylogenetic analyses of virus isolates to reexamine the hypothesis of virus movement. We sequenced a 670-nucleotide fragment of the prM/E gene region from 25 Peruvian YFV samples collected from 1977 to 1999, and delineated six clades representing the states (Departments) of Puno, Pasco, Junin, Ayacucho, San Martin/Huanuco, and Cusco. The concurrent appearance of at least four variants during the 1995 epidemic and the genetic stability of separate virus lineages over time indicate that Peruvian YFV is locally maintained and circulates continuously in discrete foci of enzootic transmission.
• Subjects:
  Animals Arbovirology Disease Outbreaks Genotype Humans Incidence Mice Molecular Epidemiology Peru Peru, Phylogeny, Yellow Fever Virus, Virus Evolution, Virus Envelope Proteins, Research Research Yellow Fever Yellow Fever Virus

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• Source:
  Emerg Infect Dis. 9(8):926-933
• Pubmed ID:
  12967489
• Pubmed Central ID:
  PMC3023271
• Document Type:
  Journal Article
• Funding:
  AI10986/AI/NIAID NIH HHS/United States
• Volume:
  9
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:dce4d8abe1b9ee252fa1b97719d59477cb45e0880992c4326f47f187e3251598
• Download URL:
  https://stacks.cdc.gov/view/cdc/14246/cdc_14246_DS1.pdf
• File Type:
  [PDF - 426.97 KB ]