Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/
Personal Author:
Messer, William B. ; Gubler, Duane J. ; Harris, Eva ; Sivananthan, Kamalanayani ; de Silva, Aravinda M.
Messer, William B. ; Gubler, Duane J. ; Harris, Eva ; Sivananthan, Kamalanayani ; de Silva, Aravinda M. Less -
Description:
Over the past two decades, dengue virus serotype 3 (DENV-3) has caused unexpected epidemics of dengue hemorrhagic fever (DHF) in Sri Lanka, East Africa, and Latin America. We used a phylogenetic approach to evaluate the roles of virus evolution and transport in the emergence of these outbreaks. Isolates from these geographically distant epidemics are closely related and belong to DENV-3, subtype III, which originated in the Indian subcontinent. The emergence of DHF in Sri Lanka in 1989 correlated with the appearance there of a new DENV-3, subtype III variant. This variant likely spread from the Indian subcontinent into Africa in the 1980s and from Africa into Latin America in the mid-1990s. DENV-3, subtype III isolates from mild and severe disease outbreaks formed genetically distinct groups, which suggests a role for viral genetics in DHF.
Subject:
[+]
Communicable Diseases, Emerging
Dengue Virus
Disease Outbreaks
Humans
Phylogeny
Research
Sequence Analysis, DNA
Severe Dengue

Source:
Emerg Infect Dis. 9(7):800-809.
Document Type:
Journal Article
Place as Subject:
Africa, Eastern ; Latin America ; Sri Lanka
Africa, Eastern ; Latin America ; Sri Lanka Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:cad4bbc740f0bd333c62a612173210f7349927b8372b1291004fc99caa1d794d
File Type:

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