Emergence and Global Spread of a Dengue Serotype 3, Subtype III Virus

Messer, William B.; Gubler, Duane J.; Harris, Eva; Sivananthan, Kamalanayani; de Silva, Aravinda M.

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Emergence and Global Spread of a Dengue Serotype 3, Subtype III Virus

Published Date:

Jul 2003

Publisher's site:

http://dx.doi.org/ New Site Icon

Source:

Emerg Infect Dis. 9(7):800-809.

[PDF-365.00 KB]

Details:

Personal Authors:

Messer, William B. ; Gubler, Duane J. ; Harris, Eva ; Sivananthan, Kamalanayani ; de Silva, Aravinda M. ;

Keywords:

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Description:

Over the past two decades, dengue virus serotype 3 (DENV-3) has caused unexpected epidemics of dengue hemorrhagic fever (DHF) in Sri Lanka, East Africa, and Latin America. We used a phylogenetic approach to evaluate the roles of virus evolution and transport in the emergence of these outbreaks. Isolates from these geographically distant epidemics are closely related and belong to DENV-3, subtype III, which originated in the Indian subcontinent. The emergence of DHF in Sri Lanka in 1989 correlated with the appearance there of a new DENV-3, subtype III variant. This variant likely spread from the Indian subcontinent into Africa in the 1980s and from Africa into Latin America in the mid-1990s. DENV-3, subtype III isolates from mild and severe disease outbreaks formed genetically distinct groups, which suggests a role for viral genetics in DHF.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

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