Emergence and Global Spread of a Dengue Serotype 3, Subtype III Virus

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Messer, William B. ; Gubler, Duane J. ; Harris, Eva ; Sivananthan, Kamalanayani ; de Silva, Aravinda M. ; Messer, William B. ; Gubler, Duane J. ; Harris, Eva ; Sivananthan, Kamalanayani ; de Silva, Aravinda M.
• Description:
  Over the past two decades, dengue virus serotype 3 (DENV-3) has caused unexpected epidemics of dengue hemorrhagic fever (DHF) in Sri Lanka, East Africa, and Latin America. We used a phylogenetic approach to evaluate the roles of virus evolution and transport in the emergence of these outbreaks. Isolates from these geographically distant epidemics are closely related and belong to DENV-3, subtype III, which originated in the Indian subcontinent. The emergence of DHF in Sri Lanka in 1989 correlated with the appearance there of a new DENV-3, subtype III variant. This variant likely spread from the Indian subcontinent into Africa in the 1980s and from Africa into Latin America in the mid-1990s. DENV-3, subtype III isolates from mild and severe disease outbreaks formed genetically distinct groups, which suggests a role for viral genetics in DHF.
• Subjects:
  Communicable Diseases, Emerging Dengue Virus Disease Outbreaks Humans Phylogeny Sequence Analysis, DNA Severe Dengue
• Source:
  Emerg Infect Dis. 9(7):800-809. ; Emerg Infect Dis. 9(7):800-809.
• Document Type:
  Journal Article
• Place as Subject:
  Africa, Eastern ; Latin America ; Sri Lanka
• Volume:
  9
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:cad4bbc740f0bd333c62a612173210f7349927b8372b1291004fc99caa1d794d
• Download URL:
  https://stacks.cdc.gov/view/cdc/14232/cdc_14232_DS1.pdf
• File Type:
  [PDF - 365.00 KB ]