Clinical Significance of Varying Degrees of Vancomycin Susceptibility in Methicillin-Resistant Staphylococcus aureus Bacteremia1

Schwaber, Mitchell J.; Wright, Sharon B.; Carmeli, Yehuda; Venkataraman, Lata; DeGirolami, Paola C.; Gramatikova, Aneta; Perl, Trish M.; Sakoulas, George; Gold, Howard S.

doi:10.3201/eid0906.030001

i

Clinical Significance of Varying Degrees of Vancomycin Susceptibility in Methicillin-Resistant Staphylococcus aureus Bacteremia1

Supporting Files

Jun 2003
By Schwaber, Mitchell J. ; Wright, Sharon B. ; Carmeli, Yehuda ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Schwaber, Mitchell J. ; Wright, Sharon B. ; Carmeli, Yehuda ; Venkataraman, Lata ; DeGirolami, Paola C. ; Gramatikova, Aneta ; Perl, Trish M. ; Sakoulas, George ; Gold, Howard S.
Description:

We conducted a retrospective study of the clinical aspects of bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) with heterogeneously reduced susceptibility to vancomycin. Bloodstream MRSA isolates were screened for reduced susceptibility by using brain-heart infusion agar, including 4 mg/L vancomycin with and without 4% NaCl. Patients whose isolates exhibited growth (case-patients) were compared with those whose isolates did not (controls) for demographics, coexisting chronic conditions, hospital events, antibiotic exposures, and outcomes. Sixty-one (41%) of 149 isolates exhibited growth. Subclones from 46 (75%) of these had a higher MIC of vancomycin than did their parent isolates. No isolates met criteria for vancomycin heteroresistance. No differences in potential predictors or in outcomes were found between case-patients and controls. These data show that patients with vancomycin-susceptible MRSA bacteremia have similar baseline clinical features and outcomes whether or not their bacterial isolates exhibit growth on screening media containing vancomycin.
Subjects:

Bacteremia Cohort Studies Electrophoresis, Gel, Pulsed-Field Female Hospitalization Humans Male Methicillin Resistance Microbial Sensitivity Tests Research Retrospective Studies Staphylococcal Infections Vancomycin Vancomycin Resistance
Source:

Emerg Infect Dis. 9(6):657-664.
Document Type:

Journal Article
Funding:

T01/CCU111438/CC/ODCDC CDC HHS/United States
Volume:

9
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:bd1b2ee27366a2f9fc312806d61ae09fbe8242a859b7fcb80c79b2ba1e9e34aa
Download URL:

https://stacks.cdc.gov/view/cdc/14214/cdc_14214_DS1.pdf
File Type:

[PDF - 345.00 KB ]

File Language:

English

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