Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome
Published Date:Mar 2004
Source:Emerg Infect Dis. 10(3):478-482.
Hantavirus Cardiopulmonary Syndrome
Hantavirus Pulmonary Syndrome
Reverse Transcriptase Polymerase Chain Reaction
Severity Of Illness Index
Sin Nombre Virus
Funding:M01 RR 00997/RR/NCRR NIH HHS/United States
R01 AI 41692/AI/NIAID NIH HHS/United States
R01 DE 14138/DE/NIDCR NIH HHS/United States
Description:Patients who later have a mild course of hantavirus cardiopulmonary syndrome (HCPS) are more likely to exhibit a high titer of neutralizing antibodies against Sin Nombre virus (SNV), the etiologic agent of HCPS, at the time of hospital admission. Because administering plasma from patients who have recovered from HCPS to those in the early stages of disease may be an advantageous form of passive immunotherapy, we examined the neutralizing antibody titers of 21 patients who had recovered from SNV infection. Even 1,000 days after admission to the hospital, 6 of 10 patients had titers of 800 or higher, with one sample retaining a titer of 3,200 after more than 1,400 days. None of the convalescent-phase serum samples contained detectable viral RNA. These results confirm that patients retain high titers of neutralizing antibodies long after recovery from SNV infection.
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