Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ye, Chunyan ; Prescott, Joseph ; Nofchissey, Robert ; Goade, Diane ; Hjelle, Brian
• Description:
  Patients who later have a mild course of hantavirus cardiopulmonary syndrome (HCPS) are more likely to exhibit a high titer of neutralizing antibodies against Sin Nombre virus (SNV), the etiologic agent of HCPS, at the time of hospital admission. Because administering plasma from patients who have recovered from HCPS to those in the early stages of disease may be an advantageous form of passive immunotherapy, we examined the neutralizing antibody titers of 21 patients who had recovered from SNV infection. Even 1,000 days after admission to the hospital, 6 of 10 patients had titers of 800 or higher, with one sample retaining a titer of 3,200 after more than 1,400 days. None of the convalescent-phase serum samples contained detectable viral RNA. These results confirm that patients retain high titers of neutralizing antibodies long after recovery from SNV infection.
• Subjects:
  Adolescent Adult Antibodies, Viral Child Female Hantavirus Pulmonary Syndrome Humans Immunization, Passive Male Reverse Transcriptase Polymerase Chain Reaction Severity Of Illness Index Sin Nombre Virus

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• Source:
  Emerg Infect Dis. 10(3):478-482.
• Document Type:
  Journal Article
• Funding:
  M01 RR 00997/RR/NCRR NIH HHS/United States ; R01 AI 41692/AI/NIAID NIH HHS/United States ; R01 DE 14138/DE/NIDCR NIH HHS/United States
• Place as Subject:
  New Mexico
• Volume:
  10
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ec5f236157330c5e64d8b882e736629322a8a44422462b35f8273c1ebe32eba2
• Download URL:
  https://stacks.cdc.gov/view/cdc/14206/cdc_14206_DS1.pdf
• File Type:
  [PDF - 162.44 KB ]