Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1003.020799
Personal Author:
Lagatolla, Cristina ; Tonin, Enrico A. ; Monti-Bragadin, Carlo ; Dolzani, Lucilla ; Gombac, Francesca ; ... More +
Lagatolla, Cristina ; Tonin, Enrico A. ; Monti-Bragadin, Carlo ; Dolzani, Lucilla ; Gombac, Francesca ; Bearzi, Claudia ; Edalucci, Elisabetta ; Gionechetti, Fabrizia ; Rossolini, Gian Maria Less -
Description:
Acquired metallo-beta-lactamases (MBLs) can confer broad-spectrum beta-lactam resistance (including carbapenems) not reversible by conventional beta-lactamase inhibitors and are emerging resistance determinants of remarkable clinical importance. In 2001, multidrug-resistant Pseudomonas aeruginosa carrying bla(VIM) MBL genes were found to be widespread (approximately 20% of all P. aeruginosa isolates and 70% of the carbapenem-resistant isolates) at Trieste University Hospital. Clonal diversity and heterogeneity of resistance determinants (either bla(VIM-1)-like or bla(VIM-2)-like) were detected among MBL producers. This evidence is the first that acquired MBLs can rapidly emerge and establish a condition of endemicity in certain epidemiologic settings.
Subject:
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Beta-Lactam Resistance Carbapenems Drug Resistance Genotype Humans Random Amplified Polymorphic DNA Technique
Source:
Emerg Infect Dis. 10(3):535-538.
Document Type:
Journal Article
Place as Subject:
Europe
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:25cd896b1032bbd8e2f500de253c01e1f7c7564ddfabc3afb63631719266665a
Download URL:
https://stacks.cdc.gov/view/cdc/14196/cdc_14196_DS1.pdf
File Type:

Supporting Files

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