Multidrug-resistant Mycobacterium tuberculosis in HIV-Infected Persons, Peru

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Campos, Pablo E. ; Suarez, Pedro G. ; Sanchez, Jorge ; Zavala, David ; Arevalo, Jorge ; Ticona, Eduardo ; Nolan, Charles M. ; Hooton, Thomas M. ; Holmes, King K.
• Description:
  During 1999 to 2000, we identified HIV-infected persons with new episodes of tuberculosis (TB) at 10 hospitals in Lima, Peru, and a random sample of other Lima residents with TB. Multidrug-resistant (MDR)-TB was documented in 35 (43%) of 81 HIV-positive patients and 38 (3.9%) of 965 patients who were HIV-negative or of unknown HIV status (p<0.001). HIV-positive patients with MDR-TB were concentrated at three hospitals that treat the greatest numbers of HIV-infected persons with TB. Of patients with TB, those with HIV infection differed from those without known HIV infection in having more frequent prior exposure to clinical services and more frequent previous TB therapy or prophylaxis. However, MDR-TB in HIV-infected patients was not associated with previous TB therapy or prophylaxis. MDR-TB is an ongoing problem in HIV-infected persons receiving care in public hospitals in Lima and Callao; they represent sentinel cases for a potentially larger epidemic of nosocomial MDR-TB.
• Subjects:
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 And Over
  • Antitubercular Agents
  • Drug Resistance, Multiple, Bacterial
  • Drug Therapy, Combination
  • Ethambutol
  • Female
  • Hiv Infections
  More +
• Source:
  Emerg Infect Dis. 9(12):1571-1578.
• Document Type:
  Journal Article
• Funding:
  AI-27757/AI/NIAID NIH HHS/United States ; T22TW00001/TW/FIC NIH HHS/United States
• Place as Subject:
  Peru
• Volume:
  9
• Issue:
  12
• Download URL:
  https://stacks.cdc.gov/view/cdc/14173/cdc_14173_DS1.pdf
• File Type:
  [PDF - 269.25 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:04678360b69f1aa50d10f22329dce97bcb9785e953c329d75dcf926ad6d42b37