Multidrug-resistant Mycobacterium tuberculosis in HIV-Infected Persons, Peru
Published Date:Dec 2003
Source:Emerg Infect Dis. 9(12):1571-1578.
Aged, 80 And Over
Drug Resistance, Multiple, Bacterial
Drug Therapy, Combination
Interviews As Topic
Microbial Sensitivity Tests
Funding:AI-27757/AI/NIAID NIH HHS/United States
T22TW00001/TW/FIC NIH HHS/United States
Description:During 1999 to 2000, we identified HIV-infected persons with new episodes of tuberculosis (TB) at 10 hospitals in Lima, Peru, and a random sample of other Lima residents with TB. Multidrug-resistant (MDR)-TB was documented in 35 (43%) of 81 HIV-positive patients and 38 (3.9%) of 965 patients who were HIV-negative or of unknown HIV status (p<0.001). HIV-positive patients with MDR-TB were concentrated at three hospitals that treat the greatest numbers of HIV-infected persons with TB. Of patients with TB, those with HIV infection differed from those without known HIV infection in having more frequent prior exposure to clinical services and more frequent previous TB therapy or prophylaxis. However, MDR-TB in HIV-infected patients was not associated with previous TB therapy or prophylaxis. MDR-TB is an ongoing problem in HIV-infected persons receiving care in public hospitals in Lima and Callao; they represent sentinel cases for a potentially larger epidemic of nosocomial MDR-TB.
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