Genotyping Analyses of Tuberculosis Cases in U.S.- and Foreign-Born Massachusetts Residents

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Sharnprapai, Sharon ; Miller, Ann C. ; Suruki, Robert ; Corkren, Edward ; Etkind, Sue ; Driscoll, Jeffrey ; McGarry, Michael ; Nardell, Edward
• Description:
  We used molecular genotyping to further understand the epidemiology and transmission patterns of tuberculosis (TB) in Massachusetts. The study population included 983 TB patients whose cases were verified by the Massachusetts Department of Public Health between July 1, 1996, and December 31, 2000, and for whom genotyping results and information on country of origin were available. Two hundred seventy-two (28%) of TB patients were in genetic clusters, and isolates from U.S-born were twice as likely to cluster as those of foreign-born (odds ratio [OR] 2.29, 95% confidence interval [CI] 1.69 to 3.12). Our results suggest that restriction fragment length polymorphism analysis has limited capacity to differentiate TB strains when the isolate contains six or fewer copies of IS6110, even with spoligotyping. Clusters of TB patients with more than six copies of IS6110 were more likely to have epidemiologic connections than were clusters of TB patients with isolates with few copies of IS6110 (OR 8.01, 95%; CI 3.45 to 18.93).
• Subjects:
  Adult Aged Child Child, Preschool Cluster Analysis DNA, Bacterial DNA Fingerprinting Emigration And Immigration Female Genotype Humans Infant Male Middle Aged Molecular Epidemiology Mycobacterium Tuberculosis Polymorphism, Restriction Fragment Length Risk Factors Tuberculosis

  More +
• Source:
  Emerg Infect Dis. 8(11):1239-1245.
• Document Type:
  Journal Article
• Place as Subject:
  Massachusetts
• Location:
  North America
• Volume:
  8
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:7a0033d2a0fe0b59385fff6be1fd91d610b86c662a9f129c0c9c294fc95efca9
• Download URL:
  https://stacks.cdc.gov/view/cdc/14056/cdc_14056_DS1.pdf
• File Type:
  [PDF - 1.19 MB ]