B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Huff, Jennifer L. ; Barry, Peter A.
• Description:
  Nonhuman primates are widely used in biomedical research because of their genetic, anatomic, and physiologic similarities to humans. In this setting, human contact directly with macaques or with their tissues and fluids sometimes occurs. Cercopithecine herpesvirus 1 (B virus), an alphaherpesvirus endemic in Asian macaques, is closely related to herpes simplex virus (HSV). Most macaques carry B virus without overt signs of disease. However, zoonotic infection with B virus in humans usually results in fatal encephalomyelitis or severe neurologic impairment. Although the incidence of human infection with B virus is low, a death rate of >70% before the availability of antiviral therapy makes this virus a serious zoonotic threat. Knowledge of the clinical signs and risk factors for human B-virus disease allows early initiation of antiviral therapy and prevents severe disease or death.
• Subjects:
  Alphaherpesvirus Animals B Virus Cercopithecine Herpesvirus 1 Communicable Diseases, Emerging Herpes B Herpesviridae Infections Herpesvirus 1, Cercopithecine Herpesvirus B Herpesvirus Simiae Humans Macaca Macaque Monkey B Virus Monkey Diseases Primate Rhesus Synopsis Viral Vaccines Zoonoses

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• Source:
  Emerg Infect Dis. 9(2):246-250
• Pubmed ID:
  12603998
• Pubmed Central ID:
  PMC2901951
• Document Type:
  Journal Article
• Funding:
  T32 RR007038/RR/NCRR NIH HHS/United States ; RR07038/RR/NCRR NIH HHS/United States
• Volume:
  9
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8280d9cdd08a8067891d9bee424cc74090d94867e5b3b6dbbbf86f7f5a3970a7
• Download URL:
  https://stacks.cdc.gov/view/cdc/14018/cdc_14018_DS1.pdf
• File Type:
  [PDF - 171.91 KB ]