Araçatuba Virus: A Vaccinialike Virus Associated with Infection in Humans and Cattle

de Souza Trindade, Giliane; Guimarães da Fonseca, Flávio; Marques, João Trindade; Nogueira, Maurício Lacerda; Mendes, Luiz Claudio Nogueira; Borges, Alexandre Secorun; Peiró, Juliana Regina; Pituco, Edviges Maristela; Bonjardim, Cláudio Antônio; Ferreira, Paulo César Peregrino; Kroon, Erna Geessien

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Araçatuba Virus: A Vaccinialike Virus Associated with Infection in Humans and Cattle

Supporting Files Public Domain

Feb 2003
By de Souza Trindade, Giliane ; Guimarães da Fonseca, Flávio ; Marques, João Trindade ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

de Souza Trindade, Giliane ; Guimarães da Fonseca, Flávio ; Marques, João Trindade ; Nogueira, Maurício Lacerda ; Mendes, Luiz Claudio Nogueira ; Borges, Alexandre Secorun ; Peiró, Juliana Regina ; Pituco, Edviges Maristela ; Bonjardim, Cláudio Antônio ; Ferreira, Paulo César Peregrino ; Kroon, Erna Geessien
Description:

We describe a vaccinialike virus, Araçatuba virus, associated with a cowpoxlike outbreak in a dairy herd and a related case of human infection. Diagnosis was based on virus growth characteristics, electron microscopy, and molecular biology techniques. Molecular characterization of the virus was done by using polymerase chain reaction amplification, cloning, and DNA sequencing of conserved orthopoxvirus genes such as the vaccinia growth factor (VGF), thymidine kinase (TK), and hemagglutinin. We used VGF-homologous and TK gene nucleotide sequences to construct a phylogenetic tree for comparison with other poxviruses. Gene sequences showed 99% homology with vaccinia virus genes and were clustered together with the isolated virus in the phylogenetic tree. Araçatuba virus is very similar to Cantagalo virus, showing the same signature deletion in the gene. Araçatuba virus could be a novel vaccinialike virus or could represent the spread of Cantagalo virus.
Subjects:

And ATI Genes Animals Araçatuba Virus Base Sequence Cattle Cattle Diseases Communicable Diseases, Emerging Cowpoxlike Outbreak Emergent Orthopoxvirus Genes, Viral HA Humans Microscopy, Electron Molecular Sequence Data Orthopoxvirus Phylogeny Research Sequence Alignment TK Vaccinia Vaccinia Virus VGF Viral Proteins Viral Structural Proteins Viremia
Source:

Emerg Infect Dis. 9(2):155-160
Pubmed ID:

12603984
Pubmed Central ID:

PMC2901946
Document Type:

Journal Article
Volume:

9
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:f841c04261f890160fc5c042af248d58a6f34ffa28150642e3a0c13e7602dd81
Download URL:

https://stacks.cdc.gov/view/cdc/14006/cdc_14006_DS1.pdf
File Type:

[PDF - 1.32 MB ]

File Language:

English

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