Induction of Inflammation by West Nile virus Capsid through the Caspase-9 Apoptotic Pathway

Yang, Joo-Sung; Ramanathan, Mathura P.; Muthumani, Karuppiah; Choo, Andrew Y.; Jin, Sung-Ha; Yu, Qian-Chun; Hwang, Daniel S.; Choo, Daniel K.; Lee, Mark D.; Dang, Kesen; Kim, J. Joseph; Weiner, David B.

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Induction of Inflammation by West Nile virus Capsid through the Caspase-9 Apoptotic Pathway

Published Date:

Dec 2002

Source:

Emerg Infect Dis. 8(12):1379-1384.

[PDF-469.21 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Yang, Joo-Sung ; Ramanathan, Mathura P. ; Muthumani, Karuppiah ; Choo, Andrew Y. ; Jin, Sung-Ha ; ... More ▼

Corporate Authors:

WaixingTang

Description:

West Nile virus (WNV) is a member of the Flaviviridae family of vector-borne pathogens. Clinical signs of WNV infection include neurologic symptoms, limb weakness, and encephalitis, which can result in paralysis or death. We report that the WNV-capsid by itself induces rapid nuclear condensation and cell death in tissue culture. Apoptosis is induced through the mitochondrial pathway resulting in caspase-9 activation and downstream caspase-3 activation. Capsid gene delivery into the striatum of mouse brain or interskeletal muscle resulted in cell death and inflammation, likely through capsid-induced apoptosis in vivo. These studies demonstrate that the capsid protein of WNV may be responsible for aspects of viral pathogenesis through induction of the apoptotic cascade.

Subject:

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Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

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