Induction of Inflammation by West Nile virus Capsid through the Caspase-9 Apoptotic Pathway

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Yang, Joo-Sung ; Ramanathan, Mathura P. ; Muthumani, Karuppiah ; Choo, Andrew Y. ; Jin, Sung-Ha ; Yu, Qian-Chun ; Hwang, Daniel S. ; Choo, Daniel K. ; Lee, Mark D. ; Dang, Kesen ; Kim, J. Joseph ; Weiner, David B.
  More +
• Corporate Authors:
  WaixingTang
• Description:
  West Nile virus (WNV) is a member of the Flaviviridae family of vector-borne pathogens. Clinical signs of WNV infection include neurologic symptoms, limb weakness, and encephalitis, which can result in paralysis or death. We report that the WNV-capsid by itself induces rapid nuclear condensation and cell death in tissue culture. Apoptosis is induced through the mitochondrial pathway resulting in caspase-9 activation and downstream caspase-3 activation. Capsid gene delivery into the striatum of mouse brain or interskeletal muscle resulted in cell death and inflammation, likely through capsid-induced apoptosis in vivo. These studies demonstrate that the capsid protein of WNV may be responsible for aspects of viral pathogenesis through induction of the apoptotic cascade.
• Subjects:
  • Research
  • West Nile Virus
  • Flavivirus
  • capsid protein
  • apoptosis
  • pathogenesis
  • Animals
  • Apoptosis
  • Brain
  • Capsid Proteins
  More +
• Source:
  Emerg Infect Dis. 8(12):1379-1384.
• Document Type:
  Journal Article
• Volume:
  8
• Issue:
  12
• Download URL:
  https://stacks.cdc.gov/view/cdc/13997/cdc_13997_DS1.pdf
• File Type:
  [PDF - 469.21 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f9909975b960c5b2dced906a4611e335808f9c55c713f50e5ed10deb02cafac1