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Induction of Inflammation by West Nile virus Capsid through the Caspase-9 Apoptotic Pathway
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Published Date:
Dec 2002
Source:Emerg Infect Dis. 8(12):1379-1384.
[PDF-469.21 KB]
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Alternative Title:Emerg Infect Dis
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Description:West Nile virus (WNV) is a member of the Flaviviridae family of vector-borne pathogens. Clinical signs of WNV infection include neurologic symptoms, limb weakness, and encephalitis, which can result in paralysis or death. We report that the WNV-capsid by itself induces rapid nuclear condensation and cell death in tissue culture. Apoptosis is induced through the mitochondrial pathway resulting in caspase-9 activation and downstream caspase-3 activation. Capsid gene delivery into the striatum of mouse brain or interskeletal muscle resulted in cell death and inflammation, likely through capsid-induced apoptosis in vivo. These studies demonstrate that the capsid protein of WNV may be responsible for aspects of viral pathogenesis through induction of the apoptotic cascade.
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