Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Yang, Joo-Sung ; Ramanathan, Mathura P. ; Muthumani, Karuppiah ; Choo, Andrew Y. ; Jin, Sung-Ha ; ... More +
Yang, Joo-Sung ; Ramanathan, Mathura P. ; Muthumani, Karuppiah ; Choo, Andrew Y. ; Jin, Sung-Ha ; Yu, Qian-Chun ; Hwang, Daniel S. ; Choo, Daniel K. ; Lee, Mark D. ; Dang, Kesen ; Kim, J. Joseph ; Weiner, David B. ; Less -
Corporate Authors:
WaixingTang ;
Description:
West Nile virus (WNV) is a member of the Flaviviridae family of vector-borne pathogens. Clinical signs of WNV infection include neurologic symptoms, limb weakness, and encephalitis, which can result in paralysis or death. We report that the WNV-capsid by itself induces rapid nuclear condensation and cell death in tissue culture. Apoptosis is induced through the mitochondrial pathway resulting in caspase-9 activation and downstream caspase-3 activation. Capsid gene delivery into the striatum of mouse brain or interskeletal muscle resulted in cell death and inflammation, likely through capsid-induced apoptosis in vivo. These studies demonstrate that the capsid protein of WNV may be responsible for aspects of viral pathogenesis through induction of the apoptotic cascade.
Subject:
[+]
Animals
Apoptosis
Brain
Capsid Protein
Capsid Proteins
Caspase 9
Caspases
Female
Flavivirus
Mice
Mice, Inbred BALB C
Pathogenesis
Research
West Nile Fever
West Nile Virus

Source:
Emerg Infect Dis. 8(12):1379-1384. ;
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:f9909975b960c5b2dced906a4611e335808f9c55c713f50e5ed10deb02cafac1
File Type:

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