Equine Amplification and Virulence of Subtype IE Venezuelan Equine Encephalitis Viruses Isolated during the 1993 and 1996 Mexican Epizootics

Gonzalez, Dante; Estrada-Franco, José G.; Carrara, Anne-Sophie; Aronson, Judith F.; Weaver, Scott C.

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Equine Amplification and Virulence of Subtype IE Venezuelan Equine Encephalitis Viruses Isolated during the 1993 and 1996 Mexican Epizootics

Supporting Files

Feb 2003
By Gonzalez, Dante ; Estrada-Franco, José G. ; Carrara, Anne-Sophie ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Gonzalez, Dante ; Estrada-Franco, José G. ; Carrara, Anne-Sophie ; Aronson, Judith F. ; Weaver, Scott C.
Description:

To assess the role of horses as amplification hosts during the 1993 and 1996 Mexican Venezuelan equine encephalitis (VEE) epizootics, we subcutaneously infected 10 horses by using four different equine isolates. Most horses showed little or no disease and low or nonexistent viremia. Neurologic disease developed in only 1 horse, and brain histopathologic examination showed meningeal lymphocytic infiltration, perivascular cuffing, and focal encephalitis. Three animals showed mild meningoencephalitis without clinical disease. Viral RNA was detected in the brain of several animals 12-14 days after infection. These data suggest that the duration and scope of the recent Mexican epizootics were limited by lack of equine amplification characteristic of previous, more extensive VEE outbreaks. The Mexican epizootics may have resulted from the circulation of a more equine-neurotropic, subtype IE virus strain or from increased transmission to horses due to amplification by other vertebrate hosts or transmission by more competent mosquito vectors.
Subjects:

Alphavirus Animals Arboviruses Brain Communicable Diseases, Emerging Encephalitis Encephalitis Virus Encephalitis Virus, Venezuelan Equine Encephalomyelitis, Venezuelan Equine Gene Amplification Histocytochemistry Horse Diseases Horses Leukocyte Count Mexico Mice Platelet Count Research Rna, Viral Temperature Venezuelan Equine Virulence
Source:

Emerg Infect Dis. 9(2):162-168
Pubmed ID:

12603985
Pubmed Central ID:

PMC2901937
Document Type:

Journal Article
Funding:

R01 AI048807/AI/NIAID NIH HHS/United States ; AI39800/AI/NIAID NIH HHS/United States ; AI48807/AI/NIAID NIH HHS/United States
Volume:

9
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:3ee2fdce98391771cb37792d4a0c506d15831a9197bdc3faefadf0b244afc7dd
Download URL:

https://stacks.cdc.gov/view/cdc/13956/cdc_13956_DS1.pdf
File Type:

[PDF - 1.40 MB ]

File Language:

English

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