Etiology of Lipid-laden Macrophages and in the Lung

Details

• Alternative Title:
  Int Immunopharmacol
• Personal Author:
  Stevenson, ER ; Smith, LC ; Wilkinson, ML ; Lee, SJ ; Gow, AJ
• Description:
  Uniquely positioned as sentinel cells constantly exposed to the environment, pulmonary macrophages are vital for the maintenance of the lung lining. These cells are responsible for the clearance of xenobiotics, pathogen detection and clearance, and homeostatic functions such as surfactant recycling. Among the spectrum of phenotypes that may be expressed by macrophages in the lung, the pulmonary lipid-laden phenotype is less commonly studied in comparison to its circulatory counterpart, the atherosclerotic lesion-associated foam cell, or the acutely activated inflammatory macrophage. Herein, we propose that lipid-laden macrophage formation in the lung is governed by lipid acquisition, storage, metabolism, and export processes. The cellular balance of these four processes is critical to the maintenance of homeostasis and the prevention of aberrant signaling that may contribute to lung pathologies. This review aims to examine mechanisms and signaling pathways that are involved in lipid-laden macrophage formation and the potential consequences of this phenotype in the lung.
• Subjects:
  Foam Cells Lipids Lung Macrophages Macrophages, Alveolar
• Source:
  Int Immunopharmacol. 123:110719
• Pubmed ID:
  37595492
• Pubmed Central ID:
  PMC10734282
• Document Type:
  Journal Article
• Funding:
  R01 HL086621/HL/NHLBI NIH HHSUnited States/ ; T32 ES007148/ES/NIEHS NIH HHSUnited States/ ; P30 ES005022/ES/NIEHS NIH HHSUnited States/ ; U01 OH012072/OH/NIOSH CDC HHSUnited States/ ; R00 ES032473/ES/NIEHS NIH HHSUnited States/ ; F32 ES030984/ES/NIEHS NIH HHSUnited States/ ; K99 ES032473/ES/NIEHS NIH HHSUnited States/
• Volume:
  123
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:275e574b5ff65f527c1f88e96aaa8c4ffb5136ae5b21576b67ee5f96d263a044e968e5de8d344bd58452b4a52d740ce7f687b1b8d53676460c348b4af97addd7
• Download URL:
  https://stacks.cdc.gov/view/cdc/138309/cdc_138309_DS1.pdf
• File Type:
  [PDF - 1.08 MB ]