Excess Mortality Associated with Antimicrobial Drug-Resistant Salmonella Typhimurium

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Helms, Morten ; Vastrup, Pernille ; Gerner-Smidt, Peter ; Mølbak, Kåre
• Description:
  In a matched cohort study, we determined the death rates associated with drug resistance in Salmonella Typhimurium. We linked data from the Danish Surveillance Registry for Enteric Pathogens with the Civil Registration System and the Danish National Discharge Registry. By survival analysis, the 2-year death rates were compared with a matched sample of the general Danish population, after the data were adjusted for differences in comorbidity. In 2,047 patients with S. Typhimurium, 59 deaths were identified. Patients with pansusceptible strains of S. Typhimurium were 2.3 times more likely to die 2 years after infection than persons in the general Danish population. Patients infected with strains resistant to ampicillin, chloramphenicol, streptomycin, sulfonamide, and tetracycline were 4.8 times (95% CI 2.2 to 10.2) more likely to die, whereas quinolone resistance was associated with a mortality rate 10.3 times higher than the general population.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Anti-Bacterial Agents Bacteriophage Typing Drug Resistance, Bacterial Humans Microbial Sensitivity Tests Middle Aged Risk Factors Salmonella Infections Salmonella Typhimurium Survival Rate

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• Source:
  Emerg Infect Dis. 8(5):490-495.
• Document Type:
  Journal Article
• Place as Subject:
  Denmark
• Volume:
  8
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:dc99557d2f9c483eb777b8ccb2ee4445d21ed8923b810b5183744ec153019258
• Download URL:
  https://stacks.cdc.gov/view/cdc/13806/cdc_13806_DS1.pdf
• File Type:
  [PDF - 228.79 KB ]