Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia

Smith, Simon; Marquardt, Tonia; Jennison, Amy V.; D’Addona, Andrew; Stewart, James; Yarwood, Trent; Ho, Jennifer; Binotto, Enzo; Harris, Julian; Fahmy, Mark; Esmonde, Juliet; Richardson, Megan; Graham, Rikki M.A.; Gair, Richard; Ariotti, Lawrence; Preston-Thomas, Annie; Rubenach, Sally; O’Sullivan, Siobhan; Allen, Darren; Ragh, Thomas; Grayson, Sachjuan; Manoy, Sophie; Warner, Jeffery M.; Meumann, Ella M.; Robson, Jennifer M.; Hanson, Josh

doi:10.3201/eid2911.230951

i

Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia

Supporting Files Public Domain

11 2023
By Smith, Simon ; Marquardt, Tonia ; Jennison, Amy V. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Smith, Simon ; Marquardt, Tonia ; Jennison, Amy V. ; D’Addona, Andrew ; Stewart, James ; Yarwood, Trent ; Ho, Jennifer ; Binotto, Enzo ; Harris, Julian ; Fahmy, Mark ; Esmonde, Juliet ; Richardson, Megan ; Graham, Rikki M.A. ; Gair, Richard ; Ariotti, Lawrence ; Preston-Thomas, Annie ; Rubenach, Sally ; O’Sullivan, Siobhan ; Allen, Darren ; Ragh, Thomas ; Grayson, Sachjuan ; Manoy, Sophie ; Warner, Jeffery M. ; Meumann, Ella M. ; Robson, Jennifer M. ; Hanson, Josh
Description:

Melioidosis, caused by the environmental gram-negative bacterium Burkholderia pseudomallei, usually develops in adults with predisposing conditions and in Australia more commonly occurs during the monsoonal wet season. We report an outbreak of 7 cases of melioidosis in immunocompetent children in Australia. All the children had participated in a single-day sporting event during the dry season in a tropical region of Australia, and all had limited cutaneous disease. All case-patients had an adverse reaction to oral trimethoprim/sulfamethoxazole treatment, necessitating its discontinuation. We describe the clinical features, environmental sampling, genomic epidemiologic investigation, and public health response to the outbreak. Management of this outbreak shows the potential benefits of making melioidosis a notifiable disease. The approach used could also be used as a framework for similar outbreaks in the future.
Subjects:

Adult Child Disease Outbreaks Genomics Humans Melioidosis
Keywords:

Bacteria Burkholderia Pseudomallei Melioidosis Pediatrics Public Health Tropical Medicine
Source:

Emerg Infect Dis. 2023; 29(11):2218-2228
Pubmed ID:

37877500
Pubmed Central ID:

PMC10617349
Document Type:

Journal Article
Place as Subject:

Australia
Volume:

29
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:f1795fcda6fc5090e78265c02f4f57584d1f2231ab946c980765da2b4f889d6f
Download URL:

https://stacks.cdc.gov/view/cdc/135981/cdc_135981_DS1.pdf
File Type:

[PDF - 5.32 MB ]

File Language:

English

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