Limitations in using multiple imputation to harmonize individual participant data for meta-analysis

Details

• Alternative Title:
  Prev Sci
• Personal Author:
  Siddique, Juned ; de Chavez, Peter J. ; Howe, George ; Cruden, Gracelyn ; Brown, C. Hendricks
• Description:
  Individual participant data (IPD) meta-analysis is a meta-analysis in which the individual-level data for each study are obtained and used for synthesis. A common challenge in IPD meta-analysis is when variables of interest are measured differently in different studies. The term harmonization has been coined to describe the procedure of placing variables on the same scale in order to permit pooling of data from a large number of studies. Using data from an IPD meta-analysis of 19 adolescent depression trials, we describe a multiple imputation approach for harmonizing 10 depression measures across the 19 trials by treating those depression measures that were not used in a study as missing data. We then apply diagnostics to address the fit of our imputation model. Even after reducing the scale of our application, we were still unable to produce accurate imputations of the missing values. We describe those features of the data that made it difficult to harmonize the depression measures and provide some guidelines for using multiple imputation for harmonization in IPD meta-analysis.
• Keywords:
  Adolescent Bias Big Data Child Data Analysis Data Synthesis Depression Female Humans Individual Participant Data Meta-analysis Male Meta-Analysis As Topic Multiple Imputation Posterior Predictive Checking Research Subjects

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• Source:
  Prev Sci. 19(Suppl 1):95-108
• Pubmed ID:
  28243827
• Pubmed Central ID:
  PMC5572105
• Document Type:
  Journal Article
• Funding:
  R01 DA018374/DA/NIDA NIH HHSUnited States/ ; R01 MH052270/MH/NIMH NIH HHSUnited States/ ; R01 MH064735/MH/NIMH NIH HHSUnited States/ ; K07 CA154862/CA/NCI NIH HHSUnited States/ ; R01 DA007031/DA/NIDA NIH HHSUnited States/ ; R37 DA007031/DA/NIDA NIH HHSUnited States/ ; R01 DA025894/DA/NIDA NIH HHSUnited States/ ; R01 MH064717/MH/NIMH NIH HHSUnited States/ ; R01 MH064707/MH/NIMH NIH HHSUnited States/ ; U01 PS000671/PS/NCHHSTP CDC HHSUnited States/ ; R01 MH049155/MH/NIMH NIH HHSUnited States/ ; R01 MH040859/MH/NIMH NIH HHSUnited States/ ; K23 MH071320/MH/NIMH NIH HHSUnited States/ ; R01 HL127491/HL/NHLBI NIH HHSUnited States/ ; R01 DA017462/DA/NIDA NIH HHSUnited States/ ; K08 MH072918/MH/NIMH NIH HHSUnited States/ ; P30 MH068685/MH/NIMH NIH HHSUnited States/
• Volume:
  19
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f9b50f5f28bbfb9d5df5c40966f8a23388cf94626553bce1f323f88cccaac16b
• Download URL:
  https://stacks.cdc.gov/view/cdc/135519/cdc_135519_DS1.pdf
• File Type:
  [PDF - 415.81 KB ]