Demographic and Operational Factors Predicting Study Completion in a Multisite Case-Control Study of Preschool Children

Details

• Alternative Title:
  Am J Epidemiol
• Personal Author:
  Bradley, Chyrise B. ; Browne, Erica N. ; Alexander, Aimee A. ; Collins, Jack ; Dahm, Jamie L. ; DiGuiseppi, Carolyn G. ; Levy, Susan E. ; Moody, Eric J. ; Schieve, Laura A. ; Windham, Gayle C. ; Young, Lisa ; Daniels, Julie L.
• Description:
  Participant attrition can limit inferences drawn from study results and inflate research costs. We examined factors associated with completion of the Study to Explore Early Development (2007-2011), a multiple-component, case-control study of risk factors for autism spectrum disorder in preschoolers, conducted in California, Colorado, Georgia, Maryland, North Carolina, and Pennsylvania. Participants (n = 3,769) were asked to complete phone interviews, questionnaires, an in-person evaluation, and biologic sampling. We examined whether participant demographic and administrative factors predicted completion using mixed-effects logistic regression models. Completion of individual key study components was generally 70% or higher. However, 58% of families completed all per-protocol data elements (defined a priori as key study components). Per-protocol completion differed according to mother's age, race, educational level, driving distance to clinic, number of contact attempts to enroll, and number of telephone numbers provided (all P < 0.05). Case status was not associated with completion, despite additional data collection for case-confirmation. Analysis of a subset that completed an early interview revealed no differences in completion by household factors of income, primary language spoken, number of adults, or number of children with chronic conditions. Differences in completion by race and education were notable and need to be carefully considered in developing future recruitment and completion strategies.
• Subjects:
  Autism Spectrum Disorder California Case-Control Studies Child, Preschool Colorado Demography Family Characteristics Female Georgia Humans Income Logistic Models Male Maryland North Carolina Pennsylvania Research Subjects Risk Factors Surveys And Questionnaires

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• Keywords:
  Attrition Child Development Completion Epidemiologic Research Design Recruitment Of Research Subjects
• Source:
  Am J Epidemiol. 187(3):592-603
• Pubmed ID:
  29506195
• Pubmed Central ID:
  PMC5963499
• Document Type:
  Journal Article
• Funding:
  U10 DD000180/DD/NCBDD CDC HHSUnited States/ ; U10 DD000181/DD/NCBDD CDC HHSUnited States/ ; U10 DD000184/DD/NCBDD CDC HHSUnited States/ ; U10 DD000182/DD/NCBDD CDC HHSUnited States/ ; U10 DD000183/DD/NCBDD CDC HHSUnited States/ ; U01 DD001210/DD/NCBDD CDC HHSUnited States/ ; U01 DD000498/DD/NCBDD CDC HHSUnited States/ ; U01 DD001205/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  187
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4749fabe466ac66fc01d15b3206aec3e3bf35cdd02568615796f32bc900b3785
• Download URL:
  https://stacks.cdc.gov/view/cdc/54370/cdc_54370_DS1.pdf
• File Type:
  [PDF - 254.75 KB ]