Establishing an Imaging Protocol for Detection of Vascularity within the Median Nerve Using Contrast-Enhanced Ultrasound

Details

• Alternative Title:
  J Diagn Med Sonogr
• Personal Author:
  Evans, Kevin D. ; Volz, Kevin R. ; Roll, Shawn C. ; Hutmire, Cristina M. ; Pargeon, Rachel L. ; Buford, John A. ; Sommerich, Carolyn M.
• Description:
  This preclinical study was conducted to develop discrete sonographic instrumentation settings and also safe contrast dosing that would consistently demonstrate perineural vascularity along the median nerve. This set of imaging studies was conducted with a convenience cohort of young adult female monkeys (|). Sonographic equipment settings and dosing were refined throughout the imaging series to ensure consistent contrast-enhanced ultrasound imaging. A mechanical index of 0.13 was consistently used for imaging. Perineural vessels were imaged with a suspension solution of 0.04 mL Definity/0.96 mL saline introduced over 5 minutes for a total dose of 0.8 mL of contrast solution. Blinded studies of high and low dose contrast, along with saline injections, were correctly identified by two experienced sonographers. This preclinical study established adequate equipment settings and dosing that allowed for a valid demonstration of vascularity surrounding the median nerve.
• Keywords:
  Contrast-enhanced Ultrasound Intraneural Vascularity Perineural Vascularity
• Source:
  J Diagn Med Sonogr. 2013; 29(5)
• Pubmed ID:
  24236299
• Pubmed Central ID:
  PMC3825188
• Document Type:
  Journal Article
• Funding:
  K12 HD055929/HD/NICHD NIH HHSUnited States/ ; R21 OH009907/OH/NIOSH CDC HHSUnited States/
• Volume:
  29
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:2d5e981e5edddf87ca700b2a98a26dc560d5a60009fa9bb88a041b8b66f1279c
• Download URL:
  https://stacks.cdc.gov/view/cdc/135036/cdc_135036_DS1.pdf
• File Type:
  [PDF - 999.17 KB ]