Associations between maternal reports of periconceptional fever from miscellaneous causes and structural birth defects

Details

• Alternative Title:
  Birth Defects Res
• Personal Author:
  Dass, Nithya Lakshmi Mohan ; Botto, Lorenzo D. ; Tinker, Sarah C. ; Canfield, Mark A. ; Finnell, Richard H. ; Gallaway, Michael Shayne ; Hashmi, Syed Shahrukh ; Hoyt, Adrienne T. ; Nembhard, Wendy N. ; Waller, Dorothy K.
• Corporate Authors:
  National Birth Defects Prevention Study
• Description:
  Background:
  
  Associations between birth defects and fevers attributed to colds, influenza, and urinary tract infections (UTIs) have been observed in previous studies. Our aim was to study associations between birth defects and fevers attributed to other causes.
  
  Methods:
  
  We analyzed data from 34,862 participants in the National Birth Defects Prevention Study, a multistate case–control study of major structural birth defects. Using multivariable logistic regression, we assessed the association between maternal report of fever during early pregnancy due to causes other than colds, influenza, or UTI and 36 categories of birth defects.
  
  Results:
  
  Maternal reports of fever due to other causes were associated with significantly elevated odds ratios ranging from 1.93 to 10.60 for 8 of 36 birth defects, primarily involving the spine, limbs, and heart (spina bifida, intestinal atresia, intercalary limb deficiency, transverse limb deficiency, congenital heart defect with heterotaxy, tetralogy of Fallot, pulmonary atresia and atrial septal defect, not otherwise specified).
  
  Conclusion:
  
  Our data suggests fever itself or other physiologic changes associated with many infections are associated with some birth defects. Women who are pregnant or planning to become pregnant may want to consider speaking with their healthcare provider about the best ways to avoid infections that may cause fever and for guidance on how to treat fevers during pregnancy.
  
  
• Keywords:
  Atrial Septal Defect Birth Defects Case-Control Studies Common Cold Congenital Heart Defect (CHD) With Heterotaxy Female Fever Heart Defects, Congenital Humans Influenza, Human Intercalary Limb Deficiency Intestinal Atresia Odds Ratio Pregnancy Pregnant Women Pulmonary Atresia Spina Bifida Tetralogy Of Fallot Transverse Limb Deficiency Urinary Tract Infections

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• Source:
  Birth Defects Res. 114(15):885-894
• Pubmed ID:
  35932236
• Pubmed Central ID:
  PMC10580304
• Document Type:
  Journal Article
• Funding:
  U01 DD000491/DD/NCBDD CDC HHSUnited States/ ; U01 DD000494/DD/NCBDD CDC HHSUnited States/ ; U01 DD001039/DD/NCBDD CDC HHSUnited States/ ; U01DD001285/ACL/ACL HHSUnited States/ ; P30 ES030285/ES/NIEHS NIH HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; EP-D-18-001/EPA/EPAUnited States/ ; U01 DD001285/DD/NCBDD CDC HHSUnited States/ ; U01 DD001229/DD/NCBDD CDC HHSUnited States/ ; CDP 13-003/HX/HSRD VAUnited States/
• Volume:
  114
• Issue:
  15
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0173eb99736bd665219152b12b867470db37c152fd148c803f97e49c2b27ecad
• Download URL:
  https://stacks.cdc.gov/view/cdc/134149/cdc_134149_DS1.pdf
• File Type:
  [PDF - 364.29 KB ]