Surveillance for Multisystem Inflammatory Syndrome in US Children Aged 5–11 Years Who Received Pfizer-BioNTech COVID-19 Vaccine, November 2021 through March 2022

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Cortese, Margaret M. ; Taylor, Allan W. ; Akinbami, Lara J. ; Thames-Allen, Andrea ; Yousaf, Anna R. ; Campbell, Angela P. ; Maloney, Susan A. ; Harrington, Theresa A. ; Gloria Anyalechi, E. ; Munshi, Datta ; Kamidani, Satoshi ; Robinette Curtis, C. ; McCormick, David W. ; Staat, Mary A. ; Edwards, Kathryn M. ; Buddy Creech, C. ; Museru, Oidda ; Marquez, Paige ; Thompson, Deborah ; Su, John R. ; Schlaudecker, Elizabeth P. ; Broder, Karen R.
• Description:
  Multisystem inflammatory syndrome in children (MIS-C) is a complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; in the United States, reporting of MIS-C after coronavirus disease 2019 (COVID-19) vaccination is required for vaccine safety monitoring. Pfizer-BioNTech COVID-19 vaccine was authorized for children aged 5-11 years on 29 October 2021. Covering a period when approximately 7 million children received vaccine, surveillance for MIS-C ≤ 90 days postvaccination using passive systems identified 58 children with MIS-C and laboratory evidence of past/recent SARS-CoV-2 infection, and 4 without evidence. During a period with extensive SARS-CoV-2 circulation, MIS-C illness in children after COVID-19 vaccination who lacked evidence of SARS-CoV-2 infection was rare (<1 per million vaccinated children).
• Keywords:
  BNT162 Vaccine Child COVID-19 COVID-19 Vaccine COVID-19 Vaccines Humans MIS-C Multisystem Inflammatory Syndrome In Children SARS-CoV-2
• Source:
  J Infect Dis. 228(2):143-148
• Pubmed ID:
  36821777
• Pubmed Central ID:
  PMC10563003
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  228
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:93c5131d6505623613f766cd0c544bff2246aac0368cc5b15b8d71424a5499ca
• Download URL:
  https://stacks.cdc.gov/view/cdc/134125/cdc_134125_DS1.pdf
• File Type:
  [PDF - 270.24 KB ]