Are individual-level risk factors for gastroschisis modified by neighborhood-level socioeconomic factors?

Details

• Alternative Title:
  Birth Defects Res
• Personal Author:
  Neo, Dayna T. ; Martin, Chantel L. ; Carmichael, Suzan L. ; Gucsavas-Calikoglu, Muge ; Conway, Kristin M. ; Evans, Shannon Pruitt ; Feldkamp, Marcia L. ; Gilboa, Suzanne M. ; Insaf, Tabassum Z. ; Musfee, Fadi I. ; Shaw, Gary M. ; Shumate, Charles ; Werler, Martha M. ; Olshan, Andrew F. ; Desrosiers, Tania A.
• Corporate Authors:
  National Birth Defects Prevention Study
• Description:
  Background:
  
  Two strong risk factors for gastroschisis are young maternal age (<20 years) and low/normal pre-pregnancy body mass index (BMI), yet the reasons remain unknown. We explored whether neighborhood-level socioeconomic position (nSEP) during pregnancy modified these associations.
  
  Methods:
  
  We analyzed data from 1269 gastroschisis cases and 10,217 controls in the National Birth Defects Prevention Study (1997–2011). To characterize nSEP, we applied the neighborhood deprivation index and used generalized estimating equations to calculate odds ratios and relative excess risk due to interaction.
  
  Results:
  
  Elevated odds of gastroschisis were consistently associated with young maternal age and low/normal BMI, regardless of nSEP. High-deprivation neighborhoods modified the association with young maternal age. Infants of young mothers in high-deprivation areas had lower odds of gastroschisis (adjusted odds ratio [aOR]: 3.1, 95% confidence interval [CI]: 2.6, 3.8) than young mothers in low-deprivation areas (aOR: 6.6; 95% CI: 4.6, 9.4). Mothers of low/normal BMI had approximately twice the odds of having an infant with gastroschisis compared to mothers with overweight/obese BMI, regardless of nSEP (aOR range: 1.5–2.3).
  
  Conclusion:
  
  Our findings suggest nSEP modified the association between gastroschisis and maternal age, but not BMI. Further research could clarify whether the modification is due to unidentified biologic and/or non-biologic factors.
  
  
• Subjects:
  Adult Female Gastroschisis Humans Infant Maternal Age Mothers Obesity Pregnancy Risk Factors Young Adult

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• Keywords:
  Age Birth Defects BMI Gastroschisis Neighborhood Socioeconomic
• Source:
  Birth Defects Res. 115(15):1438-1449
• Pubmed ID:
  37439400
• Pubmed Central ID:
  PMC10527855
• Document Type:
  Journal Article
• Funding:
  U01 DD001304/DD/NCBDD CDC HHSUnited States/ ; U01 DD001224/DD/NCBDD CDC HHSUnited States/ ; U01 DD001227/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 DD001300/DD/NCBDD CDC HHSUnited States/ ; U01 DD001032/DD/NCBDD CDC HHSUnited States/ ; U01 DD001037/DD/NCBDD CDC HHSUnited States/
• Volume:
  115
• Issue:
  15
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:64f4d1c458e9b6c01c937a70082db4aa41333335cda321f35311abfb40807b2e8e1902560ee9b5e6e0f7bad5654462aef50075437f8c106dc9c8bbeb20c60c69
• Download URL:
  https://stacks.cdc.gov/view/cdc/133497/cdc_133497_DS1.pdf
• File Type:
  [PDF - 519.43 KB ]