Design and Evaluation of a High-Flowrate Nanoparticle Respiratory Deposition (NRD) Sampler

Details

• Alternative Title:
  J Aerosol Sci
• Personal Author:
  McCollom, Theresa I. Szabo ; Stebounova, Larissa V. ; Park, Jae Hong ; Grassian, Vicki H. ; Gonzalez-Pech, Natalia I. ; Peters, Thomas M.
• Description:
  A high-flow (10 L/min) nanoparticle respiratory deposition (NRD) sampler was designed and evaluated to achieve reduced limits of quantification (LOQs) for metal nanoparticles. The high-flow NRD consists of an inlet, impactor stage, diffusion stage, and a final filter. An impactor stage with 12 nozzles was designed from theory to achieve a cut-off diameter of 300 nm at 50% particle collection efficiency (d|). Various depths of 37-mm-diameter polyurethane foam cylinders were tested for the diffusion stage to obtain a collection efficiency curve similar to the deposition of nanoparticles in the human respiratory tract, known as the nanoparticulate matter (NPM) criterion. The objective for the final filter was a collection efficiency of near 100% with minimal pressure drop. The collection efficiencies by size and pressure drops were measured for all NRD sampler components. The final design of the impactor stage nozzle achieved a d| of 305 nm. The collection efficiency for the diffusion stage with a depth of 7 cm when adjusted for presence of the impactor was the closest to the NPM curve with a R| value of 0.96 and d| of 43 nm. Chemical analysis of the metal content for foam affirmed that the high-flow NRD sampler required less sampling time to meet metal LOQs than the 2.5 L/min NRD sampler. The final filter with a modified support pad had a collection efficiency near 100%. The overall pressure drop of the sampler of 8.5 kPa (34 in. H|O) could not be handled by commercial personal sampling pumps. Hence the high-flow NRD sampler can be used as an area sampler or without the final filter for collection of nanoparticles.
• Keywords:
  Collection Efficiency Diffusion Stage Impactor Nanoparticle High-flow Sampler Pressure Drop Respiratory Deposition Curve
• Source:
  J Aerosol Sci. 134:72-79
• Pubmed ID:
  37752991
• Pubmed Central ID:
  PMC10520748
• Document Type:
  Journal Article
• Funding:
  R01 OH010238/OH/NIOSH CDC HHSUnited States/ ; T42 OH008491/OH/NIOSH CDC HHSUnited States/ ; T42OH008491/ACL/ACL HHSUnited States/
• Volume:
  134
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:2efd3de8fe8d128d66088b1775151f1a0de7182c3aea0465e2ee422fd113b654
• Download URL:
  https://stacks.cdc.gov/view/cdc/133469/cdc_133469_DS1.pdf
• File Type:
  [PDF - 829.19 KB ]